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 GREAT AMERICAN LIFE INSURANCE COMPANY

Administrative Office: P.O. Box 5423, Cincinnati OH 45201-5423

Street Address: 301 East Fourth Street, Cincinnati OH 45202

Policy Administration:
1-800-789-6771

INDEX SUMMIT 6 PRO ANNUITY

With Return of Premium Guarantee

PROSPECTUS DATED MAY 1, 2021

 The
Index Summit 6 ® Pro annuity is an Individual Index-linked Modified Single Premium Deferred Annuity contract issued by Great American Life
Insurance Company®. It provides that we will pay the Annuity Payout Benefit to you in exchange for your Purchase Payments. It also provides a Death Benefit that will never be less than the
return of premium guarantee.

 The Contract is a modified single premium deferred annuity. This means we will accept Purchase Payments only during the
purchase payment period, which ends two months after the Contract Effective Date.

 A glossary of defined terms used herein can be found in the Special
Terms section starting on page 5 of this prospectus.

 The Contract offers you the opportunity to allocate funds to Indexed Strategies for one-year or two-year Terms. Indexed Strategies provide returns based, in part, on the rise or fall of an Index, which may be a market index, such as the S&P 500 Index, or
the share price of an exchange-traded fund, such as an iShares ETF. The returns of an Index do not include reinvestment of any dividends.

 For this
Contract, we currently offer eight Indexed Strategies. Each of these Indexed Strategies uses one of three Indexes: S&P 500® Index,
iShares® MSCI EAFE ETF, and iShares® U.S. Real Estate ETF. Four of these Indexed Strategies have
one-year Terms, and four have two-year Terms.

 S&P 500 1-year Term with Cap

 S&P 500 2-year Term with Cap

S&P 500 1-year Term with Participation Rate

S&P 500 2-year Term with Participation Rate

iShares MSCI EAFE ETF 1-year Term with Participation Rate

iShares MSCI EAFE ETF 2-year Term with Participation Rate

iShares U.S. Real Estate ETF 1-year Term with Participation Rate

iShares U.S. Real Estate ETF 2-year Term with Participation Rate

All of these Indexed Strategies have a 50% Downside Participation Rate, which means that each Indexed Strategy will share 50% of any fall in the Index over a
Term.

  At the end of a Term, we may stop offering any Indexed Strategy, other than the S&P 500 1-Year Term
with Participation Rate. Consequently, any other Indexed Strategy listed above may not be available after the end of the initial Term. The S&P 500 1-Year Term with Participation Rate Indexed Strategy or
any other Indexed Strategy that may be available in the future may earn a return that is lower than the return your investments would have earned if they had been invested in the other Indexed Strategies listed above. In addition, if we reduce the
available number of Index Strategies to just the S&P 500 1-Year Term with Participation Rate Indexed Strategy, your ability to increase your Account Value could be significantly reduced.

Indexed Strategies. The value of an Indexed Strategy changes from day to day throughout each Term. The value of an Indexed Strategy is calculated using
the Investment Base.

 The Investment Base is the amount applied to the Indexed Strategy at the beginning of the current Term, reduced each day by the
Daily Charge, and adjusted proportionally for any withdrawals taken during the current Term and any related Early Withdrawal Charge. During the Term, the Investment Base remains unchanged except for the Daily Charge and any proportional adjustments
for withdrawals.

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 The Daily Charge is calculated as a percentage of the Investment Base. The Daily Charge is a rate that
compounds to 0.75% per year.

 The method used to calculate the Strategy value depends on whether the value is being calculated at the end of a Term or
during a Term.

 At the end of a Term, the value of an Indexed Strategy is the Investment Base increased for any rise in the applicable Index over the Term
or decreased for any fall in the applicable Index over the Term. For some Strategies, any increase for the Term is subject to a limit called the Cap. For others, any increase for the Term is subject to a limit called the Upside Participation Rate.
For all Strategies, any decrease for the Term resulting from Index performance is subject to a limit called the Downside Participation Rate.

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 The Cap for a Term is the largest rise in the Index over the Term taken into account to determine the Strategy
value at the end of the Term. We can change the Cap for each new Term of an Indexed Strategy. It will never be less than 1%. At least 10 days before the start of any Term, we will post the Caps for that Term on our website (www.gaig.com/RILArates).

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 If the rise in the Index is greater than or equal to the Cap, the increase applied to the remaining Investment
Base for the Term will be limited to the Cap and will be less than the rise in the Index.

•

 If the rise in the Index is less than the Cap, the increase for the Term will be less than the Cap and will equal
the rise in the Index applied to the remaining Investment Base.

•

 In both cases, the increase for a Term will always be less than the Cap or the rise in the Index because the
Daily Charge is subtracted from the Investment Base before applying the increase for the Index performance.

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 The Upside Participation Rate for a Term is the portion of any rise in the Index over the Term that is taken into
account to determine the Strategy value at the end of the Term. We can change the Upside Participation Rate for each new Term of an Indexed Strategy. It never will be less than 5%. At least 10 days before the start of any Term, we will post the
Upside Participation Rates for that Term on our website (www.gaig.com/RILArates). The increase for the Term will be less than the rise in the Index unless the Participation Rate for the Term exceeds 100%. The increase for a Term will be less than
the Upside Participation Rate multiplied by the rise in the Index because the Daily Charge is subtracted from the Investment Base before applying the increase for Index performance.

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 The Downside Participation Rate is the portion of any fall in the Index over the Term taken into account to
determine the Strategy value at the end of the Term. For each Term of each Indexed Strategy that we currently offer with this Contract, the Downside Participation Rate is 50%. In addition to the Daily Charge, the decrease for the Term will be only
half of the fall in the Index.

 Any increase in the value of an Indexed Strategy at the end of a Term is based on the value of the
underlying Index on the final Market Day of the Term. This means that you may experience negative or flat performance for the Term even though the underlying Index rose throughout some or most of the Term.

Before the end of a Term, the value of an Indexed Strategy is the Investment Base increased or decreased by the Daily Value Percentage. The Daily Value
Percentage is based on hypothetical options that represent the projected change in the Index over the full Term, and is equal to the Net Option Price, reduced by the Amortized Option Cost and the Trading Cost. The Daily Value Percentage is
applied to determine Strategy Values when you withdraw funds allocated to an Indexed Strategy or Surrender your Contract before the end of a Term. The Daily Value Percentage is also applied if the Death Benefit or Annuity
Payout value are determined before the end of a Term.

  An Indexed Strategy includes a risk of potential loss, which may include both
your original principal and prior earnings. This potential loss will exceed any decrease resulting from a fall in an Index because (i) the Daily Charge will reduce the Investment Base upon which Strategy values are based, (ii) the
decline in the Daily Value Percentage during a Term may exceed the fall in the Index, and (iii) a withdrawal or Surrender may be subject to an Early Withdrawal Charges. These same factors could cause you to realize losses even when the Index
rises. For example, you will lose value if the amount of increase attributable to an Index rise is smaller than the amount needed to offset the Daily Charge or Early Withdrawal Charge.

Availability of Indexed Strategies. One Indexed Strategy will always be available. At the end of a Term, we may eliminate a particular Indexed Strategy
in our discretion. We have the right to replace the Index associated with an Indexed Strategy under certain circumstances. A reduction in the number of available Indexed Strategies or a replacement of an underlying Index could materially limit the
growth potential of your investment in this Contract. In the future, we may offer new Indexed Strategies with Downside Participation Rates that are greater than 50%. An allocation of funds to an Indexed Strategy with a higher Downside Participation
Rate could materially increase the loss potential related to this Contract.

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 Early Withdrawal Charge. The Contract is intended for long-term investment purposes and may not be
appropriate for investors who plan to take withdrawals (including systematic withdrawals and required minimum distributions) during the first six Contract Years. During the first six Contract Years, an Early Withdrawal Charge applies if you
Surrender your Contract. It also applies to any withdrawal in excess of the Free Withdrawal Allowance, including automatic withdrawals and withdrawals taken to satisfy a required distribution. The early withdrawal charge is 9% for withdrawals and
Surrenders of the Contract in the first Contract Year, and falls each Contract Year during the six-year period. Withdrawals and Surrenders may also be subject to income tax, and withdrawals and Surrenders
before age 591⁄2 may also be subject to an additional 10% penalty tax.

Risk Factors for this Contract appear on pages 13-18 and pages 75-79.
Indexed annuity contracts are complex insurance and investment vehicles. You should speak with a financial advisor about the Index Summit 6 Pro annuity and its features, benefits, risks, and charges, and whether the Contract is appropriate for you
based upon your financial situation and objectives.

 Please read this prospectus before investing and keep it for future reference. It contains important
information about your Contract and Great American Life that you ought to know before investing. It describes all material rights and obligations under the Contract. The provisions of the Contract may vary from state to state. All material state
variations are identified in the State Variations section of this prospectus.

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NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED THESE SECURITIES OR PASSED UPON THE ADEQUACY
OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

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 The Contract is not insured by the FDIC (Federal Deposit Insurance Corporation) or the NCUSIF (National Credit
Union Share Insurance Fund).

•

 Although the Contract may be sold through relationships with banks or other financial institutions, the
Contract is not a deposit or obligation of, or guaranteed by, such institutions or any federal regulatory agency.

•

 The Contract is a security. It involves investment risk and may lose value. There is a risk of loss of
principal under the Contract and that loss can become greater due to Early Withdrawal Charges.

•

 All guarantees under the Contract are the obligations of Great American Life and are subject to the credit
worthiness and claims-paying ability of Great American Life.

 The Contract doesn’t invest in any equity, debt, or other
investments. If you buy this Contract, you aren’t investing directly in an Index, in the stocks included in S&P 500 Index, in the securities or other assets held by an iShares ETF, in any underlying index tracked by an iShares ETF, or in
the securities or other assets held by such underlying index.

 The S&P 500 Index is a product of S&P Dow Jones Indices LLC, a division of S&P
Global, or its affiliates (“SPDJI”), and has been licensed for use by Great American Life. Standard & Poor’s®,
S&P®, and S&P 500® are trademarks of Standard & Poor’s Financial Services LLC, a division of S&P Global
(“S&P”); Dow Jones® is a registered trademark of Dow Jones Trademark Holdings LLC (“Dow Jones”); and these trademarks have been licensed for use by SPDJI and
sublicensed for certain purposes by Great American Life. Great American Life products are not sponsored, endorsed, sold or promoted by SPDJI, Dow Jones, S&P or their respective affiliates, and none of such parties makes any representation
regarding the advisability of investing in such products nor do they have any liability for any errors, omissions, or interruption of the S&P 500 Index.

The iShares MSCI EAFE ETF and the iShares U.S. Real Estate ETF are distributed by BlackRock Investments, LLC. iShares®, BLACKROCK®, and the corresponding logos are registered and unregistered trademarks of BlackRock, Inc. and its affiliates
(“BlackRock”), and these trademarks have been licensed for certain purposes by Great American Life Insurance Company. Great American Life annuity products are not sponsored, endorsed, sold or promoted by BlackRock, and purchasers of an
annuity from Great American Life do not acquire any interest in the iShares MSCI EAFE ETF or the iShares U.S. Real Estate ETF nor enter into any relationship of any kind with BlackRock. BlackRock makes no representation or warranty, express or
implied, to the owners of any Great American Life annuity product or any member of the public regarding the advisability of purchasing an annuity, nor does it have any liability for any errors, omissions, interruptions or use of the iShares MSCI
EAFE ETF, the iShares U.S. Real Estate ETF or any data related thereto.

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The principal underwriter of the Contract is Great American Advisors, Inc. The offering of the Contract is intended to be continuous. The underwriter will use
its best efforts to sell the Contract.

 This prospectus is not an offering in any state, country, or jurisdiction in which we are not authorized to sell
the Contract.

 If you purchase a Contract, you may cancel it within 20 days after you receive it. If you purchase a Contract to replace an existing
annuity contract or insurance policy, you have 30 days to cancel the Contract. The right to cancel period may be longer in some states. In most states, you will bear the risk of any decreases in Indexed Strategy values before cancellation. The right
to cancel is described more fully in the Right to Cancel section of this prospectus.

 Our form number for the Contract is P1833621NW. Our form numbers for
the Indexed Strategy endorsements to the Contract are E1825418NW, E1825518NW, E1825618NW, E1825718NW, E1825818, E1825918NW, E1826018NW and E1826118NW. Our form number for the Death Benefit endorsement to this Contract is E1826318NW. The form numbers
may vary by state. The Securities and Exchange Commission file number for the Contract is 333-252949.

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 Table of Contents

 SECTION I INDEX SUMMIT 6 PRO ANNUITY INFORMATION

6

 Special Terms

6

 Special Terms Related to Daily Value Percentage

9

 Summary

10

 Risk Factors

15

 Indexed Strategies

20

 Indexes

25

 Caps and Participation Rates

27

 Indexed Strategy Value at End of Term

28

 Indexed Strategy Value before End of Term

30

 Purchase

32

 Initial Strategy Selections

33

 Strategy Selections at Term End

34

 Cash Benefit

35

 Fees and Charges

36

 Daily Charge

36

 Early Withdrawal Charge

37

 Annuity Payout Benefit

38

 Death Benefit

40

 Payout Options

42

 Processing Purchase Payments and Requests

44

 Right to Cancel (Free Look)

46

 Annual Statement and Confirmations

47

 Electronic Delivery

47

 Abandoned Property Requirements

47

 Owner

48

 Annui