SEC Company Response from IONIS PHARMACEUTICALS INC (IONS) (CIK 0000874015) (IONS) — Oct 28, 2005
IONIS PHARMACEUTICALS INC (IONS) (CIK 0000874015)
Date: Oct. 28, 2005 · CIK: 0000874015 · Accession: 0001104659-05-050910
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File numbers found in text: 333-128156
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CORRESP 1 filename1.htm October 28, 2005 VIA FACSIMILE & EDGAR Securities and Exchange Commission Division of Corporation Finance 450 Fifth Street, NW Washington, DC 20549 RE: Isis Pharmaceuticals, Inc. Form S-3 Registration Statement No. 333-128156 Ladies and Gentlemen: Pursuant to Rule 461 of Regulation C of the Securities Act of 1933, as amended, the undersigned registrant hereby requests that the Commission take appropriate action to cause the above-referenced Registration Statement No. 333-128156 to become effective at 5:00 p.m. Eastern Time on November 1, 2005 or as soon thereafter as is practicable. Very truly yours, ISIS PHARMACEUTICALS, INC. By: /s/ Patrick O’Neil Patrick O’Neil, Esq. Associate General Counsel cc: B. Lynne Parshall, Esq. Grantland E. Bryce, Esq.