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corresp

Myogen, Inc.

7575 West 103rd Avenue, Suite 102

Westminster, Colorado 80021

Tel. (303) 410-6666

Fax (303) 410-3290

November 15, 2004

Via Electronic Submission and Facsimile

Securities and Exchange Commission

450 Fifth Street, N.W.

Washington, D.C. 20549

Attention: Sonia Barros, Esq.

    Re:

    Myogen, Inc.

    Form S-3 Registration Statement No. 333-120063

Ladies and Gentlemen:

The undersigned registrant hereby requests that the Securities and Exchange
Commission take appropriate action to cause the above-referenced Registration
Statement No. 333-120063 (the “Registration Statement”) on Form S-3 to become
effective at 3:00 p.m. Eastern Standard Time on Thursday, November 18, 2004.

The disclosure in the Registration Statement is the responsibility of Myogen,
Inc. (the “Registrant”). The Registrant represents to the Securities and
Exchange Commission (the “Commission”) that should the Commission or the staff,
acting pursuant to delegated authority, declare the filing effective, it does
not foreclose the Commission from taking any action with respect to the filing
and the Registrant represents that it will not assert this action as a defense
in any proceeding initiated by the Commission or any person under the federal
securities laws of the United States.

The Registrant further acknowledges that the action of the Commission or the
staff, acting pursuant to delegated authority, in declaring the filing
effective does not relieve the Registrant from its full responsibility for the
adequacy and accuracy of the disclosure in the filing.

Please call Brent Fassett of Cooley Godward LLP at (720) 566-4025 to provide
notice of the effectiveness of the Registration Statement or if you have any
questions regarding this matter. Thank you.

Very truly yours,

    Myogen, Inc.

    By:
    /s/ J. William Freytag

    J. William Freytag

    President and Chief Executive Officer

    cc:

    James C.T. Linfield, Esq.

    Brent D. Fassett, Esq.