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Acceleration Request

 Curis, Inc.

4 Maguire Road

 Lexington, MA 02421

 August 12, 2015

VIA EDGAR

 Securities and Exchange Commission

 Division of Corporation Finance

 100 F Street, N.E.

Washington, D.C. 20549

Re:
Curis, Inc.

 Registration Statement on Form S-3

File No. 333-205460

Request for Acceleration

Ladies and Gentlemen:

 Pursuant to Rule 461
promulgated under the Securities Act of 1933, as amended, Curis, Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-205460) (the “Registration
Statement”), so that it may become effective at 4:00 pm Eastern time on August 14, 2015, or as soon thereafter as practicable.

The Registrant hereby acknowledges that:

(i)
should the Securities and Exchange Commission (the “Commission”) or the staff, acting pursuant to delegated authority, declare the Registration Statement effective, it does not foreclose the Commission from
taking any action with respect to the Registration Statement;

(ii)
the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the Registration Statement effective, does not relieve the Registrant from its full responsibility for the adequacy and
accuracy of the disclosure in the Registration Statement; and

(iii)
the Registrant may not assert staff comments and the declaration of effectiveness of the Registration Statement as a defense in any proceeding initiated by the Commission or any person under the federal securities laws
of the United States.

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 Very truly yours,

CURIS, INC.

By:

/s/ Michael P. Gray

 Name: Michael P. Gray

 Title: Chief Financial
and Chief Business

           Officer

 [Signature Page to Curis, Inc. Acceleration Request]

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