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Snell & Wilmer L.L.P.

600 Anton Boulevard

Suite 1400

Costa Mesa, California 92626

August 4, 2016

Via EDGAR

Division of Corporation
Finance

Securities and Exchange
Commission

100 F. Street, N.E.

Washington, D.C. 20549-7010

Attn.: Jay Ingram, Legal Branch Chief

 RE: Cryoport, Inc.

Registration
Statement on Form S-1

Filed June 30, 2016

File No. 333-212364

Dear Mr. Ingram:

On behalf of our client,
Cryoport, Inc. (the “Company”), we are responding to the comments of the Staff of the Securities and Exchange
Commission (the “Commission”) as set forth in your letter dated July 18, 2016 to Jerrell W. Shelton, Chief Executive
Officer of the Company, with respect to the Company’s Registration Statement on Form S-1, as filed with the Commission on
June 30, 2016. For your convenience, the Commission’s comments have been repeated herein in bold, with the Company’s
response immediately following each of the Commission’s comments.

General

 1. We note that this registration statement serves as
a post-effective amendment to your Form S-1 (File No. 333-180326), which was post-effectively amended on September 5, 2014 and
declared effective on September 18, 2014. That filing contained audited financial statements for the fiscal year ended March 31,
2014. Under Section 10(a)(3) of the Securities Act, “when a prospectus is used more than nine months after the effective
date of the registration statement, the [audited financial] information contained therein shall be as of a date not more than
sixteen months prior to such use.” Please tell us whether you have made any offers and/or sales of your common stock using
the prospectus contained in the referenced filing from July 31, 2015 to June 30, 2016, during which time the audited financial
statements in the prospectus were not current. If yes, please provide us with an analysis of your compliance with Section 5 of
the Securities Act.

August 4, 2016

Page 2

This firm has confirmed
with the Company and the Company’s transfer agent that no shares of common stock of the Company were transferred pursuant
to the prospectus made part of the Registration Statement on Form S-1 (File No. 333-180326) (the “Registration Statement”)
during the periods in which the audited financial statements contained therein were not current under Section 10(a)(3) of the Securities
Act of 1933. We believe all sales of the Company’s
restricted securities during such period by selling stockholders identified in the Registration Statement were eligible for exemption
under Section 4(1) of the Securities Act and the safe harbor provided by Rule 144.

*      *      *

As part of this response
letter, the Company acknowledges that:

 · should the Commission or the staff, acting pursuant
to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect
to the filing;

 · the action of the Commission or the staff, acting pursuant
to delegated authority, in declaring the filing effective, does not relieve the company from its full responsibility for the adequacy
and accuracy of the disclosure in the filing; and

 · the company may not assert staff comments and the declaration
of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of
the United States.

If you have any questions
regarding the above, please do not hesitate to contact the undersigned at (714) 427-7409.

Very truly yours,

Snell & Wilmer

 /s/ Anthony
J. Ippolito

Anthony J. Ippolito

 cc: Robert Stefanovich

Chief
Financial Officer