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CAPRICOR THERAPEUTICS, INC.

8840 Wilshire Blvd., 2nd Floor

Beverly Hills, CA 90211

July 13, 2017

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Irene Paik

Attention: Suzanne Hayes

 Re: Capricor Therapeutics, Inc.

Registration Statement on Form S-3

Filed July 7, 2017

File No. 333-219188

Ladies and Gentlemen:

Pursuant to Rule 461
under the Securities Act of 1933, as amended, Capricor Therapeutics, Inc., a Delaware corporation (the “Registrant”),
hereby respectfully requests that the effectiveness of the Registration Statement on Form S-3 (File No. 333-219188) of the Registrant
(the “Registration Statement”) be accelerated so that it will be declared effective at 4:30 p.m., Washington,
D.C. time, on July 17, 2017 or as soon thereafter as may be practicable. There are no underwriters for this proposed offering,
which is an offering of the Registrant’s common stock by selling stockholders.

The Registrant hereby
confirms that it is aware of its responsibilities under the Securities Act of 1933, as amended, and the Securities Exchange Act
of 1934, as amended, as they relate to the proposed offering of the securities specified in the Registration Statement. The Registrant
hereby acknowledges that:

 · should the Securities and Exchange Commission (the “Commission”) of the
staff, acting pursuant to delegated authority, declare the Registration Statement effective, it does not foreclose the Commission
from taking any action with respect to the Registration Statement;

 · the action of the Commission or the staff, acting pursuant to delegated authority, in declaring
the Registration Statement effective, does not relieve the Registrant from its full responsibility for the adequacy and accuracy
of the disclosure in the Registration Statement; and

 · the Registrant may not assert staff comments and the declaration of effectiveness as a defense
in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

The undersigned respectfully
requests that it be notified of the effectiveness of the Registration Statement by telephone call to our outside counsel, Sidley
Austin LLP, by calling Robert R. Carlson at (650) 565-7129. The Registrant hereby authorizes Mr. Carlson to orally modify or withdraw
this request for acceleration.

Please also provide
a copy of the Commission’s order declaring the Registration Statement effective to Mr. Carlson via email to rob.carlson@sidley.com
or facsimile to 650-565-7100 and via mail c/o Sidley Austin LLP, 1001 Page Mill Road, Building 1, Palo Alto, CA 94304.

    Sincerely,

    CAPRICOR THERAPEUTICS, INC.

    By: /s/ Karen Krasney, Esq.

    Name: Karen Krasney, Esq.

    Title: General Counsel & EVP

Cc:	Robert R. Carlson, Esq. (Sidley Austin LLP)