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May 22, 2020
William M. Haskel
Senior Vice President, General Counsel and Corporate Secretary
Paratek Pharmaceuticals, Inc.
75 Park Plaza
Boston, MA 02116
Re:Paratek Pharmaceuticals, Inc.
Registration Statement on Form S-3
Filed May 11, 2020
File No. 333-238150
Dear Mr. Haskel:
            We have limited our review of your registration statement to the issues we have
addressed in our comment.  Please respond to this letter by amending your registration statement
and providing the requested information.  If you do not believe our comment applies to your
facts and circumstances or do not believe an amendment is appropriate, please tell us why in
your response.
            After reviewing any amendment to your registration statement and the information you
provide in response to our comment, we may have additional comments.
Form S-3 filed May 11, 2020
General
1.We note that Section 48 of your bylaws includes a forum selection provision which
identifies the Court of Chancery of the State of Delaware as the exclusive forum for
certain litigation, including "any derivative action."  Please revise your prospectus to
clearly describe any risks or other impacts on investors. Please also disclose whether this
provision applies to actions arising under the Securities Act or Exchange Act.  In that
regard, we note that Section 27 of the Exchange Act creates exclusive federal jurisdiction
over all suits brought to enforce any duty or liability created by the Exchange Act or the
rules and regulations thereunder, and Section 22 of the Securities Act creates concurrent
jurisdiction for federal and state courts over all suits brought to enforce any duty or
liability created by the Securities Act or the rules and regulations thereunder.  If the
provision applies to Securities Act claims, please also revise your prospectus to state that
there is uncertainty as to whether a court would enforce such provision and that investors
cannot waive compliance with the federal securities laws and the rules and regulations

 FirstName LastNameWilliam M. Haskel
 Comapany NameParatek Pharmaceuticals, Inc.
 May 22, 2020 Page 2
 FirstName LastName
William M. Haskel
Paratek Pharmaceuticals, Inc.
May 22, 2020
Page 2
thereunder.  If this provision does not apply to actions arising under the Securities Act or
Exchange Act, please tell us how you will inform investors in future filings that the
provision does not apply to any actions arising under the Securities Act or Exchange Act.
            We remind you that the company and its management are responsible for the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action or absence of
action by the staff.
            Refer to Rules 460 and 461 regarding requests for acceleration.  Please allow adequate
time for us to review any amendment prior to the requested effective date of the registration
statement.
            Please contact Abby Adams at (202) 551-6902 or Joseph McCann at (202) 551-6262 with
any questions.
Sincerely,
Division of Corporation Finance
Office of Life Sciences