SecProbe.io

April 25, 2012
 Via E-mail

Antonius Schuh, Ph.D Chief Executive Officer Trovagene, Inc. 11055 Flintkote Avenue, Suite B San Diego, CA  92121
Re: Trovagene, Inc.
  Registration Statement on Form S-1
Filed April 19, 2012
  File No. 333-180810

Dear Dr. Schuh:
 We have limited our review of your registrati on statement to the issue we have addressed
in our comment below.
 After reviewing any amendment to your regi stration statement, we may have additional
comments.

 We note that at time of filing of the re gistration statement you were not required to
include interactive data exhibits (XBRL) pursuan t to Item 601(b)(101) of Regulation S-K.
Please note, however, that you will  be required to include inter active data exhibits with any
amendment to the registration statement if you am end the registration statement after the 30 day
grace period following the due date of your Fo rm 10-Q for the quarter ending March 31, 2012.

We urge all persons who are responsible for th e accuracy and adequacy of the disclosure
in the filing to be certain that the filing incl udes the information the Securities Act of 1933 and
all applicable Securities Act rules require.  Since the company and its management are in
possession of all facts relating to a company’s disc losure, they are responsible for the accuracy
and adequacy of the disclosures they have made.
Notwithstanding our comments, in the event you request acceleration of  the effective date
of the pending registration statement please pr ovide a written statement from the company
acknowledging that:

 should the Commission or the staff, acting purs uant to delegated authority, declare the
filing effective, it does not foreclose the Co mmission from taking any action with respect
to the filing;

Antonius Schuh, Ph.D Trovagene, Inc. April 25, 2012 Page 2

  the action of the Commission or the staff, acting pursuant to delegated authority, in
declaring the filing effective, does not relieve the company from its full responsibility for
the adequacy and accuracy of the disclosure in the filing; and

 the company may not assert staff comments a nd the declaration of effectiveness as a
defense in any proceeding initiated by the Commission or any person under the federal
securities laws of the United States.  Please refer to Rules 460 and 461 regarding re quests for acceleration.  We will consider a
written request for acceleration of  the effective date of the regi stration statement as confirmation
of the fact that those reques ting acceleration are aware of thei r respective responsibilities under
the Securities Act of 1933 and the Securities Excha nge Act of 1934 as they relate to the proposed
public offering of the securities specified in th e above registration stat ement.  Please allow
adequate time for us to review any amendment prior to the requested effective date of the
registration statement.
 Please contact Karen Ubell at (202) 551-3873 or me at (202) 551-3715 with any
questions.
Sincerely,
   /s/ Jeffrey Riedler
Jeffrey Riedler Assistant Director