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CORRESP Filing

Opus Genetics, Inc.
Date: April 21, 2026 · CIK: 0001228627 · Accession: 0001140361-26-015777

Offering / Registration Process

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File numbers found in text: 333-294295

Date
April 21, 2026
Author
/s/ Dr. George Magrath
Form
CORRESP
Company
Opus Genetics, Inc.

Letter

April 21, 2026

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-3720

Attention:

Jessica Dickerson

Re:

Opus Genetics, Inc.

Registration Statement on Form S-3

File No. 333-294295

Acceleration Request

Requested Date: April 22, 2026

Requested Time: 4:00 P.M., Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Opus Genetics, Inc. (the “Company”) hereby requests that the effective date of the above-referenced Registration Statement on Form S-3 (as amended, the “Registration Statement”), be accelerated so that the Registration Statement will become effective at 4:00 P.M., Eastern Time, on April 22, 2026, or as soon thereafter as practicable or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the U.S. Securities and Exchange Commission.

Please contact Nick DeAngelis of Sidley Austin LLP at (214) 969-3563 with any questions regarding the foregoing and to confirm the effectiveness of the Registration Statement.

Very truly yours,
/s/ Dr. George Magrath

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CORRESP
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      April 21, 2026

      Via EDGAR

      U.S. Securities and Exchange Commission

      Division of Corporation Finance

      100 F Street, N.E.

      Washington, D.C. 20549-3720

            Attention:

            Jessica Dickerson

             Re:

            Opus Genetics, Inc.

            Registration Statement on Form S-3

            File No. 333-294295

            Acceleration Request

            Requested Date:   April 22, 2026

            Requested Time:  4:00 P.M., Eastern Time

      Ladies and Gentlemen:

      Pursuant to Rule 461 under the Securities Act of 1933, as amended, Opus Genetics, Inc. (the “Company”) hereby requests that the effective
        date of the above-referenced Registration Statement on Form S-3 (as amended, the “Registration Statement”), be accelerated so that the Registration Statement will become effective at 4:00
        P.M., Eastern Time, on April 22, 2026, or as soon thereafter as practicable or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the U.S. Securities and
        Exchange Commission.

      Please contact Nick DeAngelis of Sidley Austin LLP at (214) 969-3563 with any questions regarding the foregoing and to confirm the effectiveness of the Registration Statement.

            Very truly yours,

            /s/ Dr. George Magrath

            Dr. George Magrath

            Chief Executive Officer

            Opus Genetics, Inc.

            cc:

            Robert Gagnon, Opus Genetics, Inc.

            Asher Rubin, Sidley Austin LLP

            Istvan A. Hajdu, Sidley Austin LLP

            Nick DeAngelis, Sidley Austin LLP