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CORRESP Filing

CRESCENT BIOPHARMA, INC.
Date: May 13, 2025 · CIK: 0001253689 · Accession: 0001104659-25-047721

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File numbers found in text: 333-285035

Date
May 13, 2025
Author
Brian Hahn
Form
CORRESP
Company
CRESCENT BIOPHARMA, INC.

Letter

VIA EDGAR Division of Corporation Finance Office of Life Sciences Securities and Exchange Commission Attention: Jessica Dickerson Registration Statement on Form S-4, as amended Filed on February 18, 2025, as amended on April 4, 2025, April 29, 2025 and May 12, 2025 File No. 333-285035 (as amended, the “Registration Statement”) Request for Acceleration

Dear Ms. Dickerson,

Pursuant to Rule 461 of the Rules and Regulations of the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended, GlycoMimetics, Inc. (the “Company”) hereby respectfully requests acceleration of the effective date of the Registration Statement, so that it may become effective at 4:01 p.m., Eastern Time, on May 14, 2025, or as soon thereafter as practicable. The Company hereby authorizes each of Asher M. Rubin, John H. Butler, and Kostian Ciko of Sidley Austin LLP, counsel to the Company, to make such request on its behalf.

Once the Registration Statement is effective, please orally confirm the event with the Company’s counsel, Sidley Austin LLP by calling Kostian Ciko at (212) 839-5450. The Company also respectfully requests that a copy of the written order from the Commission verifying the effective time and date of the Registration Statement be sent to kciko@sidley.com.

Should any member of the staff of the Commission have any questions or comments with respect to this request, please contact our counsel, Sidley Austin LLP, by calling Kostian Ciko at (212) 839-5450.

Very truly yours,
GLYCOMIMETICS, INC.

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CORRESP
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GlycoMimetics, Inc.

P.O. Box 65

Monrovia, Maryland 21770

(240) 243-1201

May 13, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

Securities and Exchange Commission

Washington, D.C. 20549

Attention: Jessica Dickerson

    Re:
    GlycoMimetics, Inc.

Registration Statement on Form S-4, as amended

Filed on February 18, 2025, as amended on April
4, 2025, April 29, 2025 and May 12, 2025

File No. 333-285035 (as amended, the “Registration
Statement”)

Request for Acceleration

Dear Ms. Dickerson,

Pursuant
to Rule 461 of the Rules and Regulations of the Securities and Exchange Commission (the “Commission”) under
the Securities Act of 1933, as amended, GlycoMimetics, Inc. (the “Company”) hereby respectfully requests acceleration
of the effective date of the Registration Statement, so that it may become effective at 4:01 p.m., Eastern Time, on May 14, 2025, or as
soon thereafter as practicable. The Company hereby authorizes each of Asher M. Rubin, John H. Butler, and Kostian Ciko of Sidley
Austin LLP, counsel to the Company, to make such request on its behalf.

Once
the Registration Statement is effective, please orally confirm the event with the Company’s counsel, Sidley Austin LLP by
calling Kostian Ciko at (212) 839-5450. The Company also respectfully requests that a copy of the written order from the Commission verifying
the effective time and date of the Registration Statement be sent to kciko@sidley.com.

Should any member of the staff
of the Commission have any questions or comments with respect to this request, please contact our counsel, Sidley Austin LLP, by calling
Kostian Ciko at (212) 839-5450.

    Very truly yours,

    GLYCOMIMETICS, INC.

    By:
    /s/ Brian Hahn

    Brian Hahn

    Principal Executive and Financial Officer

    cc:

    Asher M. Rubin, Esq., Sidley Austin LLP

    John H. Butler, Esq., Sidley Austin LLP

    Kostian Ciko, Esq., Sidley Austin LLP

    Ryan A. Murr, Esq., Gibson, Dunn & Crutcher LLP

    Branden C. Berns, Esq., Gibson, Dunn & Crutcher LLP