SecProbe.io

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    K&L Gates llp

    1601 K Street NW

    Washington, DC 20006-1600

    T 202.778.9000         www.klgates.com

September 1, 2009

Eric S. Purple

D 202.778.9220

F 202.778-9100

eric.purple@klgates.com

By E-mail and EDGAR

Mr. Larry Greene

Division of Investment Management

Securities and Exchange Commission

100 F Street, N.E., Room 4700

Washington, D.C. 20549

Attn: Mr. Larry Greene

    Re:

     Calamos Global Total Return Fund (File Nos. 333-146944 and 811-21547) Registration
 Statement
on Form N-2 Relating to Universal Shelf Offering

Dear Mr. Greene:

     On August 21, 2009, Calamos Global Total Return Fund (the “Fund”) filed Post-Effective
Amendment No. 2 to its Registration Statement on Form N-2 (the “Amendment”) for the purpose of: (1)
providing updated financial information and (2) making conforming language changes in response to
the Commission staff’s comments on substantially identical disclosure contained in the Registration
Statements for certain related funds, as described below. The purpose of this letter is to request
selective review of the Amendment, in accordance with the Commission’s release on selective review,
Revised Procedures For Processing Registration Statements, Post-Effective Amendments and
Preliminary Proxy Materials Filed by Registered Investment Companies, Investment Company Act
Release No. 13768 (February 15, 1984).

     In connection with the Fund’s 2008 universal shelf registration of Common Shares, Preferred
Shares and Debt Securities, the SEC staff reviewed the Fund’s prospectus, forms of prospectus
supplement and statement of additional information. The Fund is requesting selective review of
those portions of the Amendment that are identical to (or substantially identical to) the
registration statement previously filed for the purpose of registering its common shares of
beneficial interest (“Common Shares”), preferred shares of beneficial interest (“Preferred
Shares”), debt securities (“Debt Securities”), or any combination of Common Shares, Preferred
Shares or Debt Securities,
with a proposed maximum aggregate offering price of $75,000,000 (the “Shelf Registration
Statement”), which was declared effective in March 2008.

     In addition, much of the disclosure relating to the description of securities and plan of
distribution is substantially identical to disclosure in recent universal shelf registration
statements or amendments thereto (the “Other Calamos Fund Registration Statements”) relating to
common shares of beneficial interest, preferred shares of beneficial interest and debt securities
filed by:

Division of Investment Management

September 1, 2009

Page 2

    •

    Calamos Convertible Opportunities and Income Fund (File Nos. 333-146945 and
811-21080) (“CHI”);

    •

    Calamos Convertible and High Income Fund (File Nos. 333-146947 and 811-21319)
(“CHY”);

    •

    Calamos Global Dynamic Income Fund (File Nos. 333-153443 and 811-22047) (“CHW”); and

    •

    Calamos Strategic Total Return Fund (File Nos. 333-146943 and 811-21484) (“CSQ” and
together with CHI, CHY and CHW, the “Other Calamos Funds”).

     The Other Calamos Funds are closed-end investment companies managed by Calamos Advisors LLC,
the investment adviser of the Fund. After the Commission staff provided comments and reviewed the
responses to those comments, the Commission declared the Post-Effective Amendments to each of CHI’s
and CHY’s Registration Statements effective in April 2009. The Commission also previously declared
the CSQ Registration Statement effective in March 2008, after several rounds of comment letters and
responses. In addition, the Commission staff has reviewed the CHW Registration Statement and
provided comments in January 2009, March 2009 and August 2009. The Fund is requesting selective
review of those portions of the Shelf Registration Statement that are identical to (or
substantially identical to) the Other Calamos Fund Registration Statements, and therefore have been
subject to review by the Commission staff.

     As we have discussed, overall, the only substantive differences between the Amendment and the
Shelf Registration Statement and Other Calamos Fund Registration Statements, as appropriate, are:

    •

    the Amendment reflects the redemption of all of the Fund’s outstanding Auction Rate
Cumulative Preferred Shares (“ARPS”), and, as such, does not include the ARPS-specific
disclosure changes requested by the Commission staff during its review of the Other
Calamos Fund Registration Statements; and

    •

    the Amendment describes the terms of the Committed Facility Agreement with BNP
Paribas Prime Brokerage, Inc. (as successor to Bank of America N.A.) that allows the
Fund to borrow up to an initial limit of $59,000,000.

     Other than as described above, the description of securities and the plan of distribution
disclosed in the Amendment are substantially identical to the same portions of the Shelf
Registration Statement and Other Calamos Fund Registration Statements.

     In the paragraphs that follow, I have indicated the specific sections of the Shelf
Registration Statement with respect to which the Fund is requesting selective review.

Division of Investment Management

September 1, 2009

Page 3

     Please note that I have not indicated in the description below all places where changes were
made to update dates or other information, to reflect the fact that the Fund no longer has ARPS
outstanding, or other changes of a minor or conforming nature.

Prospectus

     Cover Page —The disclosure on the cover page is substantially identical to the
corresponding disclosure in the same location for the Other Calamos Funds.

     Prospectus Summary — I have listed below those subsections of the section captioned
“Prospectus Summary” that are substantially identical to disclosure previously subject to review by
the Commmission staff, and for which the Fund is requesting selective review.

     The Fund; Investment Adviser; The Offering; Use of Proceeds; and Dividends and Distributions
on Common Shares. The disclosure in these subsections is substantially identical to the
corresponding disclosure in the Other Calamos Funds’ Registration Statements.

     Investment Policies. The disclosure in these subsections is substantially identical to the
corresponding disclosure in the Shelf Registration Statement.

     Use of Leverage by the Fund; Interest Rate Transactions; and Conflicts of Interest. The
disclosure in this subsection is substantially identical to the corresponding disclosure in the
Other Calamos Funds’ Registration Statements.

     Fund Risks. The disclosure in this subsection is substantially identical to the disclosure in
the corresponding subsections of the Shelf Registration Statement and the Other Calamos Funds’
Registration Statements.

     Additional Risks to Common Shareholders; and Additional Risks to Senior Security Holders. The
disclosure in this subsection is substantially identical to the corresponding disclosure in the
Other Calamos Funds’ Registration Statements.

     Summary of Fund Expenses; Financial Highlights; Market and Net Asset Value Information;
and Use of Proceeds — The disclosure in these sections (aside from specific financial data) is
substantially identical to the corresponding sections of the Other Calamos Funds’ Registration
Statements.

     The Fund; and Investment Objective and Strategies — The disclosure in these sections
is substantially identical to the corresponding sections of the Shelf Registration Statement,
except for
the disclosure under the subsection “Conflicts of Interest”, which is substantially identical
to the corresponding subsection of the Other Calamos Funds’ Registration Statements.

     Leverage; and Interest Rate Transactions — The disclosure in these sections is
substantially identical to the corresponding sections of the Other Calamos Funds’ Registration
Statements.

Division of Investment Management

September 1, 2009

Page 4

     Risk Factors — The disclosure in this subsection is substantially identical to the
disclosure in the corresponding subsections of the Shelf Registration Statement and the Other
Calamos Funds’ Registration Statements, except for the disclosure under the subsections “Additional
Risks to Common Shareholders” and “Additional Risks to Senior Security Holders”, which is
substantially identical to the corresponding subsection of the Other Calamos Funds’ Registration
Statements.

     Management of the Fund — This section is substantially identical to the corresponding
sections of the Shelf Registration Statement and the Other Calamos Funds’Registration Statements.

     Closed-End Fund Structure; Certain Federal Income Tax Matters; Net Asset Value; Dividends
and Distributions on Common Shares; Automatic Dividend Reinvestment Plan; Description of
Securities; Rating Agency Guidelines; Plan of Distribution; Legal Matters; Experts; and Table of
Contents of Statement of Additional Information — The disclosure in these sections is
substantially identical to disclosure in the corresponding sections of the Other Calamos Funds’
Registration Statements. Please note that, as discussed, there is new disclosure in the
Description of Securities section that describes the describes the terms of the Committed Facility
Agreement with BNP Paribas Prime Brokerage, Inc.

     Certain Provisions of the Agreement and Declaration of Trust and By-Laws, Including
Antitakeover Provisions; Custodian, Transfer Agent, Dividend Disbursing Agent and Registrar; and
Available Information — The disclosure in these sections is substantially identical to
disclosure in the corresponding sections of the Shelf Registration Statement and the Other Calamos
Funds’ Registration Statements.

     Form of Prospectus Supplements — The forms of prospectus supplements included in the
Amendment are substantially identical to the corresponding sections in the Other Calamos Funds’
Registration Statements.

Prospectus Supplement Relating to Common Shares

     Cover Page —The disclosure on the cover page is substantially identical to the
corresponding disclosure in the same location for the Other Calamos Funds.

     Prospectus Supplement Summary — I have listed below those subsections of the section
captioned “Prospectus Supplement Summary” that are substantially identical to disclosure previously
subject to review by the Commission staff, and for which the Fund is requesting selective review.

     The Fund; Investment Adviser; The Offering; and Use of Proceeds. The disclosure in these
subsections is substantially identical to the corresponding disclosure in the Other Calamos Funds’
Registration Statements.

     Capitalization; Financial Highlights; Summary of Fund Expenses; Market and Net Asset Value
Information; Use of Proceeds; Plan of Distribution; Legal Matters; Experts; and Available

Division of Investment Management

September 1, 2009

Page 5

Information — The disclosure in these sections (aside from specific financial data) is
substantially identical to the corresponding sections of the Other Calamos Funds’ Registration
Statements.

Statement of Additional Information

     The disclosure in the Statement of Additional Information included in the Amendment is
substantially identical to the disclosure in the statement of additional information included in
the Other Calamos Funds’ Registration Statements, except for the disclosure in the “Investment
Objective and Policies” section, which is substantially identical to the corresponding disclosure
in the Shelf Registration Statement.

     Appendix A of the Statement of Additional Information (“Description of Ratings”) is
substantially identical to Appendix C of the statement of additional information included in the
Shelf Registration Statement, and Appendix B of the statement of additional information included in
the Other Calamos Funds’ Registration Statements.

     Please call me or David P. Glatz (312-807-4295) if you have any questions about the enclosed,
or if you require anything further.

Very truly yours,

Eric S. Purple

Enclosures

    cc:

    Stathy Darcy

    Paulita A. Pike