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SmartMetric, Inc.

3960 Howard Hughes Parkway, Suite 500

Las Vegas, Nevada 89169

June 23, 2022

VIA EDGAR

U.S. Securities & Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

    Re:
    SmartMetric, Inc.

    Registration Statement on Form S-1

    Filed May 23, 2022, as amended

    File No. 333-265152

Ladies and Gentlemen:

In accordance with Rule 461 of the Securities
Act of 1933, as amended, SmartMetric, Inc. (the “Company”) hereby respectfully requests that the effective date of
the above-captioned Registration Statement on Form S-1 (the “Registration Statement”) be accelerated so that it will
be declared effective at 4:00 p.m. Eastern Time on Monday, June 27, 2022, or as soon thereafter as possible.

Please contact Andrea Cataneo (email: ajc@msk.com
or telephone: (917) 546-7702) of Mitchell Silberberg & Knupp LLP with any questions and kindly notify her when this request for acceleration
has been granted.

Very truly yours,

    SmartMetric, Inc.

    /s/ Chaya Hendrick

    Chaya Hendrick

    Chief Executive Officer

Exhibit 5.1

    Mitchell Silberberg & Knupp
    llp

    A Law Partnership Including
    Professional Corporations

June 23, 2022

SmartMetric, Inc.

3960 Howard Hughes Parkway

Suite 500

Las Vegas, Nevada 89169

 Re: Registration Statement on
Form S-1

Ladies and Gentlemen:

We have acted as counsel to
SmartMetric, Inc., a Nevada corporation (the “Company”), in connection with its filing with the Securities and Exchange
Commission of a Registration Statement on Form S-1 (the “Registration Statement”), pursuant to the Securities Act of
1933, as amended (the “Act”), filed on June 14, 2022, relating to the proposed resale from time to time of 50,000,000
shares of the Company’s common stock, par value $0.001 per share, (the “Common Stock”), 50,000,000 warrants to purchase
shares of the Common Stock (the “Warrants”) and 162,500,000 shares of Common Stock issuable upon the exercise of the
Warrants (the “Warrant Shares”). All of the securities to be offered are held by persons who are shareholders of the
Company (the “Selling Shareholders”).

The Shares and Warrants
are to be sold by the Company pursuant to certain securities purchase agreements (each a “Purchase Agreement”) entered into
by and between the Company and the Selling Shareholders. The securities are to be offered and sold in the manner described in the Registration
Statement and the related prospectus included therein (the “Prospectus”).

In connection therewith, we
have examined and relied upon original, certified, conformed, photostat or other copies of (a) the Amended and Restated Articles of Incorporation
and the Bylaws of the Company; (b) resolutions of the Board of Directors of the Company; (c) the Registration Statement and the exhibits
thereto; and (d) such corporate records of the Company, certificates of public officials, certificates of officers of the Company and
other documents, agreements and instruments as we have deemed necessary as a basis for the opinions herein contained. In all such examinations,
we have assumed the genuineness of all signatures on original documents, and the conformity to originals or certified documents of all
copies submitted to us as conformed, photostat or other copies. In passing upon certain corporate records and documents of the Company,
we have necessarily assumed the correctness and completeness of the statements made or included therein by the Company, and we express
no opinion thereon.

We have further assumed the
legal capacity of natural persons, and we have assumed that each party to the documents we have examined or relied on (other than the
Company) has the legal capacity or authority and has satisfied all legal requirements that are applicable to that party to the extent
necessary to make such documents enforceable against that party. We have also assumed that all of the shares of Common Stock issuable
or eligible for issuance pursuant to exercise of the Warrants following the date hereof will be issued for not less than par value.

    437 Madison Ave., 25th Floor, New York, New York 10022-7001

Phone:  (212) 509-3900  Fax:  (212) 509-7239  Website: www.msk.com

June 23, 2022

Page 2

Based on the foregoing, we
are of the opinion that:

1. Common Stock.
When the Registration Statement becomes effective under the Act and when the offering is completed as contemplated by the Registration
Statement, the shares of Common Stock will be validly issued, fully paid and non-assessable.

3. Warrants.
When the Registration Statement becomes effective under the Act and when the Warrants are issued, delivered and paid for, as contemplated
by the Registration Statement, such Warrants will be legally binding obligations of the Company enforceable in accordance with their terms
except: (a) as such enforceability may be limited by bankruptcy, insolvency, reorganization or similar laws affecting creditors’
rights generally and by general equitable principles (regardless of whether enforceability is considered in a proceeding in equity or
at law); (b) as enforceability of any indemnification or contribution provision may be limited under the federal and state securities
laws; (c) that the remedy of specific performance and injunctive and other forms of equitable relief may be subject to the equitable defenses
and to the discretion of the court before which any proceeding therefor may be brought; and (d) we express no opinion as to whether a
state court outside of the State of New York or a federal court of the United States would give effect to the choice of New York law provided
for in the Warrants.

3. Common Stock
underlying Warrants. When the Registration Statement becomes effective under the Act and when the offering is completed as contemplated
by the Registration Statement, the shares of Common Stock issuable upon exercise of the Warrants will be validly issued, fully paid and
non-assessable.

We are attorneys admitted
to practice in New York. We are familiar with the applicable provisions of the Nevada Revised Statutes, the applicable provisions
of the Nevada Constitution and reported judicial decisions interpreting these laws, and we have made such inquiries with respect thereto
as we consider necessary to render this opinion with respect to a Nevada corporation. This opinion letter is opining upon and is limited
to the current federal securities laws of the United States and, as set forth above, Nevada law, including the statutory provisions, all
applicable provisions of the Nevada Constitution and reported judicial decisions interpreting those laws, as such laws presently exist
and to the facts as they presently exist. We express no opinion with respect to the effect or applicability of the laws of any other jurisdiction.
Our opinion is based on these laws as in effect on the date hereof and as of the effective date of the Registration Statement, and we
assume no obligation to revise or supplement this opinion after the effective date of the Registration Statement should the law be changed
by legislative action, judicial decision or otherwise. Where our opinions expressed herein refer to events to occur at a future date,
we have assumed that there will have been no changes in the relevant law or facts between the date hereof and such future date. Our opinions
expressed herein are limited to the matters expressly stated herein and no opinion is implied or may be inferred beyond the matters expressly
stated. Not in limitation of the foregoing, we are not rendering any opinion as to the compliance with any other federal or state law,
rule or regulation relating to securities, or to the sale or issuance thereof.

June 23, 2022

Page 3

We hereby consent to the use
of this opinion as an exhibit to the Registration Statement, to the use of our name as the Company’s counsel and to all references
made to us in the Registration Statement and in the prospectus forming a part thereof. In giving this consent, we do not admit that we
are in the category of persons whose consent is required under Section 7 of the Act, or the rules and regulations promulgated thereunder.
This opinion is given as of the effective date of the Registration Statement, and we are under no duty to update the opinions contained
herein.

    Very truly yours,

    /s/ MITCHELL SILBERBERG & KNUPP LLP