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CORRESP Filing

Lyra Therapeutics, Inc.
Date: July 28, 2025 · CIK: 0001327273 · Accession: 0001193125-25-166724

Offering / Registration Process

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File numbers found in text: 333-288872

Date
July 28, 2025
Author
L YRA T HERAPEUTICS , I NC .
Form
CORRESP
Company
Lyra Therapeutics, Inc.

Letter

Re: LYRA THERAPEUTICS, INC. Registration Statement on Form S-1 (Registration No. 333-288872) Ladies and Gentlemen: In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the Registration Statement on Form S-1 (Registration No. 333-288872) (as amended, the “Registration Statement”) of Lyra Therapeutics, Inc. (the “Company”). We respectfully request that the Registration Statement become effective as of 4:30 p.m., Eastern Time, on July 30, 2025, or at such later time as the Company or its counsel may orally request via telephone call to the staff. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Latham & Watkins LLP, by calling Wesley C. Holmes at (617) 948-6027. If you have any questions regarding the foregoing, please do not hesitate to contact Peter N. Handrinos at (617) 948-6060 or Wesley C. Holmes at (617) 948-6027, of Latham & Watkins LLP. Thank you in advance for your consideration.

LYRA THERAPEUTICS, INC. 480 Arsenal Way Watertown, MA 02472 July 28, 2025 V IA EDGAR T RANSMISSION Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, NE Washington, D.C. 20549 Attention: Juan Grana

Very truly yours,
L YRA T HERAPEUTICS , I NC .

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CORRESP
 1
 filename1.htm

 CORRESP

 LYRA THERAPEUTICS, INC.
 480 Arsenal Way Watertown, MA
02472 July 28, 2025 V IA EDGAR
T RANSMISSION Securities and Exchange Commission
 Division of Corporation Finance Office of Industrial
Applications and Services 100 F Street, NE Washington, D.C.
20549 Attention:  Juan Grana

 Re:
 LYRA THERAPEUTICS, INC.
    Registration Statement on Form S-1 (Registration
No. 333-288872) Ladies and Gentlemen:
 In accordance with Rule 461 under the Securities Act of 1933, as amended, we hereby request acceleration of the effective date of the
Registration Statement on Form S-1 (Registration No. 333-288872) (as amended, the “Registration Statement”) of Lyra Therapeutics, Inc. (the
“Company”). We respectfully request that the Registration Statement become effective as of 4:30 p.m., Eastern Time, on July 30, 2025, or at such later time as the Company or its counsel may orally request via telephone call to the
staff. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Latham & Watkins LLP, by calling Wesley C. Holmes at (617) 948-6027.
 If you have any questions regarding the foregoing, please do not hesitate to contact Peter N. Handrinos at (617) 948-6060 or Wesley C. Holmes at (617) 948-6027, of Latham & Watkins LLP. Thank you in advance for your consideration.

 Very truly yours,

 L YRA T HERAPEUTICS , I NC .

 By:

 /s/ Jason Cavalier

 Name:

 Jason Cavalier

 Title:

 Chief Financial Officer

 cc:
 Peter N. Handrinos, Latham & Watkins LLP
 Wesley C. Holmes, Latham & Watkins LLP