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CORRESP Filing

PALISADE BIO, INC.
Date: Sept. 29, 2025 · CIK: 0001357459 · Accession: 0001493152-25-015909

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File numbers found in text: 333-290568

Date
Sept. 29, 2025
Author
Director
Form
CORRESP
Company
PALISADE BIO, INC.

Letter

Ladenburg Thalmann & Co. Inc.

Fifth Avenue, 4 th Floor

New York, New York 10019

September 29, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

F Street, N.E.

Washington, DC 20549

Re: Palisade Bio, Inc.

Registration Statement on Form S-1 (Registration No. 333-290568)

Concurrence in Acceleration Request

Ladies and Gentlemen:

Ladenburg Thalmann & Co. Inc. (" Ladenburg "), as representative of the underwriters for the referenced offering, hereby concurs in the request by Palisade Bio, Inc. that the effective date of the above-referenced registration statement be accelerated to 9:00 a.m. (Eastern Time), or as soon as practicable thereafter, on October 1, 2025, pursuant to Rule 461 under the Securities Act. Ladenburg affirms that it is aware of its obligations under the Securities Act in connection with this offering.

Very
truly yours,
LADENBURG
THALMANN & CO. INC.

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CORRESP
 1
 filename1.htm

 Ladenburg
Thalmann & Co. Inc.

 640
Fifth Avenue, 4 th Floor

 New
York, New York 10019

 September
29, 2025

 VIA
EDGAR

 U.S.
Securities and Exchange Commission

 Division
of Corporation Finance

 100
F Street, N.E.

 Washington,
DC 20549

 Re:
 Palisade
 Bio, Inc.

 Registration
 Statement on Form S-1 (Registration No. 333-290568)

 Concurrence
 in Acceleration Request

 Ladies
and Gentlemen:

 Ladenburg
Thalmann & Co. Inc. (" Ladenburg "), as representative of the underwriters for the referenced offering, hereby concurs
in the request by Palisade Bio, Inc. that the effective date of the above-referenced registration statement be accelerated to 9:00
a.m. (Eastern Time), or as soon as practicable thereafter, on October 1, 2025, pursuant to Rule 461 under the Securities Act.
Ladenburg affirms that it is aware of its obligations under the Securities Act in connection with this offering.

 Very
 truly yours,

 LADENBURG
 THALMANN & CO. INC.

 By:
 /s/
 Nicholas Stergis

 Name:

 Nicholas
 Stergis

 Title:

 Managing
 Director