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Correspondence 0001493152-26-024460 from PALISADE BIO, INC. (PALI)

PALISADE BIO, INC.
Date: May 19, 2026 · CIK: 0001357459 · Accession: 0001493152-26-024460

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File numbers found in text: 333-295815

Date
May 12, 2026
Author
Chief
Form
CORRESP
Company
PALISADE BIO, INC.

Letter

Palisade Bio, Inc.

South Syracuse Street, Suite 900

Denver, Colorado 80237

May 19, 2026

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

F Street N.E.

Washington, D.C. 20549

Re: Palisade Bio, Inc.

Registration Statement on Form S-3

Filed May 12, 2026

File No. 333-295815

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 to become effective at 4:30 p.m. Eastern Time on May 21, 2026, or as soon thereafter as is practicable.

The Registrant hereby authorizes Jeffrey C. Thacker of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP, counsel to the Registrant, to orally modify or withdraw this request for acceleration.

Thank you for your assistance. If you should have any questions, please contact Jeffrey C. Thacker of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP, counsel to the Registrant, at (858) 436-8046.

Very truly yours,
Palisade Bio, Inc.

Show Raw Text
CORRESP
 1
 filename1.htm

 Palisade
Bio, Inc.

 4600
South Syracuse Street, Suite 900

 Denver,
Colorado 80237

 May
19, 2026

 VIA
EDGAR

 U.S.
Securities and Exchange Commission

 Division
of Corporation Finance

 100
F Street N.E.

 Washington,
D.C. 20549

 Re:
 Palisade
 Bio, Inc.

 Registration
 Statement on Form S-3

 Filed
 May 12, 2026

 File
 No. 333-295815

 Ladies
and Gentlemen:

 Pursuant
to Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange
Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 to become effective at 4:30 p.m.
Eastern Time on May 21, 2026, or as soon thereafter as is practicable.

 The
Registrant hereby authorizes Jeffrey C. Thacker of Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP, counsel to the
Registrant, to orally modify or withdraw this request for acceleration.

 Thank
you for your assistance. If you should have any questions, please contact Jeffrey C. Thacker of Gunderson Dettmer Stough Villeneuve Franklin
& Hachigian, LLP, counsel to the Registrant, at (858) 436-8046.

 Very truly yours,

 Palisade Bio, Inc.

 By:
 /s/
 J.D. Finley

 J.D.
 Finley

 Chief
 Executive Officer

 Palisade
 Bio, Inc.

 cc:
 Jeffrey
 C. Thacker, Gunderson Dettmer Stough Villeneuve Franklin & Hachigian, LLP