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SEC Company Response from Milestone Pharmaceuticals (MIST) — May 20, 2026

Milestone Pharmaceuticals Inc.
Date: May 20, 2026 · CIK: 0001408443 · Accession: 0001104659-26-064183

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File numbers found in text: 333-295860

Date
May 20, 2026
Author
By
Form
CORRESP
Company
Milestone Pharmaceuticals Inc.

Letter

Milestone Pharmaceuticals Inc. 1111 Dr. Frederik-Philips Boulevard, Suite 420 Montréal, Québec CA H4M 2X6

VIA EDGAR

May 20, 2026

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Tyler Howes

Re: Milestone Pharmaceuticals Inc.

Registration Statement on Form S-3 File No. 333-295860

Acceleration Request

Requested Date: Friday, May 22, 2026

Requested Time: 4:00 P.M. Eastern Time

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the " Registrant ") hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-295860) (the " Registration Statement ") to become effective on Friday, May 22, 2026, at 4:00 p.m. Eastern Time, or as soon thereafter as is practicable, or at such other time as its legal counsel, Cooley LLP, may request by telephone to the Staff.

The Registrant hereby authorizes each of Ryan S. Sansom and Peter Byrne of Cooley LLP to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Peter Byrne of Cooley LLP, counsel to the undersigned registrant, at (212) 479-6778.

[ Signature Page Follows ]

Sincerely,
Milestone Pharmaceuticals Inc.

Show Raw Text
CORRESP
 1
 filename1.htm

 Milestone Pharmaceuticals Inc.
1111 Dr. Frederik-Philips Boulevard, Suite 420
Montréal, Québec CA H4M 2X6

 VIA EDGAR

 May 20, 2026

 U.S. Securities and Exchange Commission

 Division of Corporation Finance

 100 F Street, N.E.

 Washington, D.C. 20549

 Attn: Tyler Howes

 Re:
 Milestone Pharmaceuticals Inc.

 Registration Statement on Form S-3
File No. 333-295860

 Acceleration Request

 Requested Date:
 Friday, May 22, 2026

 Requested Time:
 4:00 P.M. Eastern Time

 Ladies and Gentlemen:

 In accordance with Rule 461 under the Securities
Act of 1933, as amended, the undersigned registrant (the " Registrant ") hereby requests that the Securities and
Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-295860)
(the " Registration Statement ") to become effective on Friday, May 22, 2026, at 4:00 p.m. Eastern
Time, or as soon thereafter as is practicable, or at such other time as its legal counsel, Cooley LLP, may request by telephone to the
Staff.

 The Registrant hereby authorizes each of Ryan S. Sansom and Peter Byrne
of Cooley LLP to make such request on its behalf.

 Once the Registration Statement has been declared
effective, please orally confirm that event with Peter Byrne of Cooley LLP, counsel to the undersigned registrant, at (212) 479-6778.

 [ Signature
Page Follows ]

 Sincerely,

 Milestone Pharmaceuticals Inc.

 By:

 /s/ Joseph Oliveto

 Joseph Oliveto

 Chief Executive Officer

 cc: Amit Hasija, Milestone Pharmaceuticals Inc.

 Ryan S. Sansom, Cooley LLP

 Peter Byrne, Cooley LLP