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CORRESP
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    701
                                            Wild Rose Lane

                                            Elk City, ID, 83525

    4093
    Oceanside Blvd. Suite B

    Oceanside, CA, 92056

U.S.
Securities and Exchange Commission

Division
of Corporate Finance

Office
of Industrial Applications and Services

100
F Street, N.E.

Washington,
D.C. 20549-7561

    Re:
    Therapeutic
    Solutions International, Inc. (TSOI)

    Registration
    Statement on Form S-1A

    File
    No.: 333-268070

January
30, 2023

Ladies
and Gentlemen:

This
correspondence is Therapeutic Solutions International, Inc.’s, (“TSOI”) response to your comments letter of January
27, 2023 and describes how each of the comments has been addressed in the amended filing of January 30, 2023, S-1A, Amendment Three (3).

Risk
Factors, page 20

Comment
1: We note your revisions in response to our prior comment 2. We note that you are registering up to 555,000,000 shares and that
the purchase price under the equity financing agreement is defined based on the trading price of your common stock. Given this, please
expand your risk factor titled “We may not have access to the full amount under the Financing Agreement” to discuss the impact
of the trading price per share on your ability to access the full amount available under the equity financing agreement pursuant to this
registration statement, or advise. We note that at your current share price, 555,000,000 shares have a value between $3 and $4 million.

Response:
The Risk Factor titled “We may not have access to the full amount under the Financing Agreement” has been amended to discuss
the impact of the trading price (if it remains too low) may affect the Company’s ability to access the full amount under the securities
Purchase Agreement with GHS.

Executive
Compensation, page 46

Comment
2: Please update your compensation disclosure for your recently completed fiscal year ended December 31, 2022. For guidance, see
Item 402 of Regulation S-K and Question 117.05 of Regulation S-K Compliance and Disclosure Interpretations.

Response:
The compensation disclosure has been updated as of the recently completed fiscal year ended December 31, 2022.

General

Comment
3: We note your revisions in response to our prior comment 6 and reissue in part. Your prospectus still contains some references
to incorporating by reference. Please revise the below statements to remove the references to incorporating by reference Exchange Act
filings:

●
on the Cover Page, “See “Risk Factors” beginning on page 20 and the risk factors in our most recent Annual Report on
Form 10-K, as well as in any other recently filed quarterly or current reports and, if any, in the relevant prospectus supplement. We
urge you to carefully read this Prospectus, its exhibits, together with the documents we are entitled to incorporate by reference, if
any, describing the terms of these securities before investing”; and

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    701
                                            Wild Rose Lane

                                            Elk City, ID, 83525

    4093
    Oceanside Blvd. Suite B

    Oceanside, CA, 92056

●
on page F-15, it states that “The following discussion and analysis should be read in conjunction
with the accompanying financial statements and related notes, as well as the Financial Statements and related notes in our Annual Report
on Form 10-K for the fiscal year ended December 31, 2021 and the risk factors discussed therein filed with the SEC” and under Item
1A. Risk Factors, that “No material changes to risk factors have occurred as previously disclosed in Item 1A of our Annual Report
on Form 10-K for the year ended December 31, 2021, which was filed with the SEC on March 31, 2022.”

Response:
All references to “incorporating by reference” have been removed.

It
would be appreciated if, as soon practicable, you would inform the company and Hugh Kelso at (619) 840-5056, if there are any additional
actions required

    Very
    truly yours,

    Therapeutic
    Solutions International, Inc.

    By:
    /s/:
    Timothy G. Dixon

    Timothy
    G. Dixon

    Chief
    Executive Officer

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