SecProbe.io

CORRESP
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Skyline Medical Inc.

2915 Commers Drive, Suite 900

Eagan, Minnesota 55121

October 3, 2016

BY EDGAR

United States Securities and Exchange Commission

100 F Street, NE

Washington, D.C. 20549

Attention: Ms. Heather Percival

    Re:
    Skyline Medical Inc.

    Registration Statement on Form S-3

    File No. 333-213766

    Request for Acceleration

Ladies and Gentlemen:

In accordance with Rule 461 of the General
Rules and Regulations under the Securities Act of 1933, as amended, Skyline Medical Inc., a Delaware corporation (the “Registrant”),
hereby requests that the effectiveness of the above-referenced Registration Statement on Form S-3 (the “Registration Statement”),
be accelerated so that it will be declared effective at 3:00 p.m. Eastern time on October 4, 2016, or as soon thereafter as practicable.

The Registrant hereby acknowledges that:

(i)
should the Securities and Exchange Commission (the “Commission”) or the staff, acting pursuant to delegated
authority, declare the Registration Statement effective, it does not foreclose the Commission from taking any action with respect
to the Registration Statement;

(ii)
the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the Registration Statement
effective, does not relieve the Registrant from its full responsibility for the adequacy and accuracy of the disclosure in the
Registration Statement; and

(iii)
the Registrant may not assert staff comments and the declaration of the effectiveness as a defense in any proceeding initiated
by the Commission or any person under the federal securities laws of the United States.

[Signature page follows]

    Very truly yours,

    Skyline Medical Inc.

    By: /s/ Bob Myers

    Name: Bob Myers

    Title: Chief Financial Officer

[Signature Page to Acceleration Request]