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OptimizeRx
Corp

June
6, 2018

THE
UNITED STATES SECURITIES

AND
EXCHANGE COMMISSION

Attn:
Edwin Kim

Division
of Corporation Finance

Mail
Stop 7010

100
F. Street NE

Washington,
D.C. 20549-7010

    Re:
    OptimizeRx
    Corp

    Registration Statement
    on Form S-1

    File No. 333-225095

Dear
Mr. Kim:

Pursuant
to Rule 461 under the Securities Act of 1933, as amended, OptimizeRx Corp (the “Company”) hereby requests acceleration
of the effective date of its Registration Statement on Form S-1 to 4:00 PM Eastern Standard Time on June 8, 2018, or as soon thereafter
as is practicable.

The
Company acknowledges the following:

 ● Should
                                         the Commission or the staff, acting pursuant to delegated authority, declare the filing
                                         effective, it does not foreclose the Commission from taking any action with respect to
                                         the filing;

 ● The
                                         action of the Commission or the staff, acting pursuant to delegated authority, in declaring
                                         the filing effective, does not relieve the Company from its full responsibility for the
                                         adequacy and accuracy of the disclosure in the filing; and

 ● The
                                         Company may not assert staff comments and the declaration of effectiveness as a defense
                                         in any proceeding initiated by the Commission or any person under the federal securities
                                         laws of the United States.

Thank
you for your assistance. Please call with any questions.

    OptimizeRx
    Corp

    By:
    /s/
    Doug Baker

    Doug Baker

    Chief Financial Officer

400
Water Street Suite 200

Rochester,
MI, 48307- Phone: 248 651-6568