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SEC Comment Letter for Karyopharm Therapeutics (KPTI) — May 7, 2026

Karyopharm Therapeutics Inc.
Date: May 7, 2026 · CIK: 0001503802 · Accession: 0000000000-26-004695

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File numbers found in text: 333-295535

Date
May 7, 2026
Author
Division of
Form
UPLOAD
Company
Karyopharm Therapeutics Inc.

Letter

Re: Karyopharm Therapeutics Inc. Registration Statement on Form S-3 Filed May 4, 2026 File No. 333-295535 Dear Richard Paulson:

May 7, 2026

Richard Paulson President and Chief Executive Officer Karyopharm Therapeutics Inc. 85 Wells Avenue, 2nd Floor Newton, MA 02459

This is to advise you that we have not reviewed and will not review your registration statement.

Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff.

Please contact Alan Campbell at 202-551-4224 with any questions.

Sincerely,
Division of
Corporation Finance
Office of Life
Sciences
cc: Craig Hilts

Show Raw Text
<DOCUMENT>
<TYPE>TEXT-EXTRACT
<SEQUENCE>2
<FILENAME>filename2.txt
<TEXT>
 May 7, 2026

Richard Paulson
President and Chief Executive Officer
Karyopharm Therapeutics Inc.
85 Wells Avenue, 2nd Floor
Newton, MA 02459

 Re: Karyopharm Therapeutics Inc.
 Registration Statement on Form S-3
 Filed May 4, 2026
 File No. 333-295535
Dear Richard Paulson:

 This is to advise you that we have not reviewed and will not review your
registration
statement.

 Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

 Please contact Alan Campbell at 202-551-4224 with any questions.

 Sincerely,

 Division of
Corporation Finance
 Office of Life
Sciences
cc: Craig Hilts
</TEXT>
</DOCUMENT>