Correspondence 0001193125-22-314423 from Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802) (KPTI)
Karyopharm Therapeutics Inc. (KPTI) (CIK 0001503802)
Date: Dec. 29, 2022 · CIK: 0001503802 · Accession: 0001193125-22-314423
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File numbers found in text: 333-268991
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CORRESP 1 filename1.htm Acceleration Request December 29, 2022 VIA EDGAR SUBMISSION Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, DC 20549 Attention: Tim Buchmiller Re: Karyopharm Therapeutics Inc. Registration Statement on Form S-3 File No. 333-268991 Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended, Karyopharm Therapeutics Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-268991), so that it may become effective at 4:30 p.m., Eastern Time, on January 3, 2023, or as soon as practicable thereafter, or at such later time as the Registrant or its counsel may orally request via telephone call to the staff. Very truly yours, KARYOPHARM THERAPEUTICS INC. By: /s/ Michael Mano Name: Michael Mano Title: Senior Vice President and General Counsel cc: Jason Kropp, Wilmer Cutler Pickering Hale and Dorr LLP Craig Hilts, Wilmer Cutler Pickering Hale and Dorr LLP