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CORRESP Filing

SYNLOGIC, INC.
Date: Aug. 18, 2025 · CIK: 0001527599 · Accession: 0001193125-25-182671

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File numbers found in text: 333-289415

Date
August 18, 2025
Author
Mary Beth Dooley
Form
CORRESP
Company
SYNLOGIC, INC.

Letter

SYNLOGIC, INC. PO Box 30 Winchester, Massachusetts 01890 August 18, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ms. Doris Stacey Gama Re: Synlogic, Inc. Registration Statement on Form S-3 Filed August 8, 2025 File No. 333-289415 (the “Registration Statement”) Acceleration Request Ladies and Gentlemen: In accordance with Rule 461 of Regulation C promulgated under the Securities Act of 1933, as amended, Synlogic, Inc. (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Wednesday, August 20, 2025, at 4:01 p.m., Eastern Time, or as soon as thereafter practicable. The cooperation of the staff in meeting the timetable described above is very much appreciated. Please contact Nishant Dharia, Esq. of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (212) 692-8174 with any questions regarding this request.

Very truly yours,
SYNLOGIC, INC.

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CORRESP
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 CORRESP

 SYNLOGIC, INC.
 PO Box 30 Winchester,
Massachusetts 01890 August 18, 2025 VIA EDGAR
 U.S. Securities and Exchange Commission Division of
Corporation Finance 100 F Street, N.E.
 Washington, D.C. 20549 Attention: Ms. Doris Stacey Gama
 Re: Synlogic, Inc. Registration Statement on Form
 S-3 Filed August 8, 2025
 File No. 333-289415 (the “Registration Statement”)
 Acceleration Request Ladies and
Gentlemen: In accordance with Rule 461 of Regulation C promulgated under the Securities Act of 1933, as amended, Synlogic, Inc. (the
“Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Wednesday, August 20, 2025, at 4:01 p.m., Eastern Time, or as
soon as thereafter practicable. The cooperation of the staff in meeting the timetable described above is very much appreciated.
 Please contact Nishant Dharia, Esq. of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (212) 692-8174 with any questions regarding this request.

 Very truly yours,

 SYNLOGIC, INC.

 /s/ Mary Beth Dooley

 Mary Beth Dooley Principal Executive Officer
and Principal Financial Officer

 cc:
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
 Daniel A. Bagliebter, Esq.
 Nishant Dharia, Esq.