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Correspondence 0001193125-22-309125 from Syros Pharmaceuticals, Inc. (SYRS) (CIK 0001556263)

Syros Pharmaceuticals, Inc. (SYRS) (CIK 0001556263)
Date: Dec. 20, 2022 · CIK: 0001556263 · Accession: 0001193125-22-309125

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File numbers found in text: 333-267888

Date
December 20, 2022
Author
Chief Legal Officer
Form
CORRESP
Company
Syros Pharmaceuticals, Inc. (SYRS) (CIK 0001556263)

Letter

December 20, 2022

VIA EDGAR SUBMISSION

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, NE

Washington, DC 20549

Attention: Lauren Hamill

Tim Buchmiller

Re: Syros Pharmaceuticals, Inc.

Registration Statement on Form S-3

File No. 333-267888

Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Syros Pharmaceuticals, Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-267888), so that it may become effective at 4:00 p.m., Eastern Time, on December 22, 2022, or as soon as practicable thereafter.

Very truly yours,
SYROS PHARMACEUTICALS, INC.

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CORRESP
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filename1.htm

CORRESP

 December 20, 2022

VIA EDGAR SUBMISSION

 Securities and Exchange
Commission

 Division of Corporation Finance

 100 F Street, NE

 Washington, DC 20549

Attention:
 Lauren Hamill

Tim Buchmiller

Re:
 Syros Pharmaceuticals, Inc.

Registration Statement on Form S-3

File No. 333-267888

Request for Acceleration

 Ladies and
Gentlemen:

 Pursuant to Rule 461 under the Securities Act of 1933, as amended, Syros Pharmaceuticals, Inc. hereby requests acceleration of the effective
date of its Registration Statement on Form S-3 (File No. 333-267888), so that it may become effective at 4:00 p.m., Eastern Time, on December 22, 2022, or as
soon as practicable thereafter.

Very truly yours,

SYROS PHARMACEUTICALS, INC.

By:

 /s/ Gerald E. Quirk

Name:

Gerald E. Quirk

Title:

Chief Legal Officer