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CollPlant Holdings Ltd. 3

Sapir Street, Weizmann
Science Park

Ness Ziona 74140, Israel

February 21, 2019

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

    Re:
    CollPlant Holdings Ltd.

        Registration Statement on Form F-3

        File No. 333- 229486

VIA EDGAR

Ladies and Gentlemen:

Pursuant to Rule 461 under
the Securities Act of 1933, as amended, CollPlant Holdings Ltd. (the “Registrant”) hereby respectfully requests
that the effectiveness of the Registration Statement on Form F-3 (File No. 333-229486) of the Registrant (the “Registration
Statement”) be accelerated so that it will be declared effective at 4:30 p.m., Eastern Time, on February 22, 2019 or
as soon thereafter as may be practicable.

The Registrant hereby confirms
that it is aware of its responsibilities under the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934,
as amended, as they relate to the proposed offering of the securities specified in the Registration Statement. The Registrant hereby
acknowledges that:

•  should the Securities
                                         and Exchange Commission (the “Commission”) or the staff, acting pursuant
                                         to delegated authority, declare the Registration Statement effective, it does not foreclose
                                         the Commission from taking any action with respect to the Registration Statement;

•  the action of the Commission or the staff, acting pursuant to delegated authority,
in declaring the Registration Statement effective, does not relieve the Registrant from its full responsibility for the adequacy
and accuracy of the disclosure in the filing; and

•  the Registrant may not assert staff comments and the declaration of effectiveness
as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

The
undersigned respectfully requests that it be notified of the effectiveness of the Registration Statement by telephone call to
our counsel, McDermott Will & Emery LLP, by calling Gary Emmanuel at (917) 297-4545. The Company hereby authorizes Mr. Emmanuel
to orally modify or withdraw this request for acceleration.

Please also provide a
copy of the Commission’s order declaring the Registration Statement effective to Mr. Emmanuel via email to gemmanuel@mwe.com
or facsimile to (212) 547-5444 and via mail at 340 Madison Avenue, New York, NY 10173.

    Very truly
yours,

    COLLPLANT
HOLDINGS LTD.

    By:
    /s/ Eran Rotem

    Name: Eran Rotem
Title: Deputy CEO and Chief Financial
Officer

cc:  Gary Emmanuel (McDermott Will & Emery LLP)