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CORRESP Filing

ACTUATE THERAPEUTICS, INC.
Date: July 31, 2025 · CIK: 0001652935 · Accession: 0001683168-25-005548

Offering / Registration Process

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File numbers found in text: 333-288952

Date
July 31, 2025
Author
President and Chief
Form
CORRESP
Company
ACTUATE THERAPEUTICS, INC.

Letter

Actuate Therapeutics, Inc. 1751 River Run, Suite 400

Fort Worth, TX 76107

July 31, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Tyler Howes

Re: Actuate Therapeutics, Inc. Registration Statement on Form S-1 File No. 333-288952

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the " Act "), Actuate Therapeutics, Inc. (the " Company ") hereby requests that the effective date of the above-referenced registration statement (the " Registration Statement ") be accelerated to August 4, 2025, at 5:00 p.m., Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Baker & Hostetler LLP, request by telephone that such Registration Statement be declared effective at some other time. In making this acceleration request, the Company acknowledges that it is aware of its obligations under the Act.

We request that we be notified of such effectiveness by a telephone call to Janet Spreen of Baker & Hostetler LLP, counsel to the Company, at (216) 861-7564 and that such effectiveness also be confirmed in writing.

Very truly yours,
Actuate Therapeutics, Inc.

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CORRESP
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 filename1.htm

 Actuate Therapeutics, Inc.
 1751 River Run, Suite 400

 Fort Worth, TX 76107

 July 31, 2025

 VIA EDGAR

 U.S. Securities and Exchange Commission

 Division of Corporation Finance

 100 F Street, N.E.

 Washington, D.C. 20549

 Attn: Tyler Howes

 Re:
 Actuate Therapeutics, Inc.
Registration Statement on Form S-1
File No. 333-288952

 Ladies and Gentlemen:

 Pursuant to Rule 461 under the Securities Act
of 1933, as amended (the " Act "), Actuate Therapeutics, Inc. (the " Company ") hereby requests that
the effective date of the above-referenced registration statement (the " Registration Statement ") be accelerated to
August 4, 2025, at 5:00 p.m., Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Baker & Hostetler
LLP, request by telephone that such Registration Statement be declared effective at some other time. In making this acceleration request,
the Company acknowledges that it is aware of its obligations under the Act.

 We request that we be notified of such effectiveness
by a telephone call to Janet Spreen of Baker & Hostetler LLP, counsel to the Company, at (216) 861-7564 and that such effectiveness
also be confirmed in writing.

 Very truly yours,

 Actuate Therapeutics, Inc.

 By: /s/ Daniel M. Schmitt                              

        Daniel M. Schmitt

        President and Chief
Executive Officer