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SEC Company Response from Q32 Bio Inc. (QTTB) (CIK 0001661998) (QTTB) — Mar 23, 2018

Q32 Bio Inc. (QTTB) (CIK 0001661998)
Date: March 23, 2018 · CIK: 0001661998 · Accession: 0001193125-18-094014

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File numbers found in text: 333-223409

Date
March 23, 2018
Author
Director
Form
CORRESP
Company
Q32 Bio Inc. (QTTB) (CIK 0001661998)

Letter

Re: Homology Medicines, Inc.

March 23, 2018

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Registration Statement on Form S-1 (as amended) (SEC File No. 333-223409)

Ladies and Gentlemen:

In connection with the above-referenced Registration Statement, and pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), we hereby join in the request of Homology Medicines, Inc. that the effective date of the Registration Statement be accelerated so that it will be declared effective at 4:00 p.m., New York City time, on March 27, 2018, or as soon thereafter as practicable.

Pursuant to Rule 460 under the Act, please be advised that we have distributed approximately 870 copies of the Preliminary Prospectus dated March 19, 2018 through the date hereof, to underwriters, dealers, institutions and others, and are in the process of redistributing the preliminary prospectus dated March 23, 2018 (the “Preliminary Prospectus”) to those investors as well.

In connection with the Preliminary Prospectus distribution for the above-referenced issue, the prospective underwriters have confirmed that they are complying with the 48-hour requirement in Rule 15c2-8(b) under the Securities Exchange Act of 1934, as amended.

Very truly yours,
MERRILL LYNCH, PIERCE, FENNER & SMITH

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CORRESP
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CORRESP

 March 23, 2018

Securities and Exchange Commission

 100 F Street, N.E.

Washington, D.C. 20549

Re:
Homology Medicines, Inc.

Registration Statement on Form S-1 (as amended) (SEC File No. 333-223409)

Ladies and Gentlemen:

 In connection with the above-referenced
Registration Statement, and pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), we hereby join in the request of Homology Medicines, Inc. that the effective date of the Registration Statement be
accelerated so that it will be declared effective at 4:00 p.m., New York City time, on March 27, 2018, or as soon thereafter as practicable.

 Pursuant to
Rule 460 under the Act, please be advised that we have distributed approximately 870 copies of the Preliminary Prospectus dated March 19, 2018 through the date hereof, to underwriters, dealers, institutions and others, and are in the process of
redistributing the preliminary prospectus dated March 23, 2018 (the “Preliminary Prospectus”) to those investors as well.

 In connection with
the Preliminary Prospectus distribution for the above-referenced issue, the prospective underwriters have confirmed that they are complying with the 48-hour requirement in Rule
15c2-8(b) under the Securities Exchange Act of 1934, as amended.

 Very truly yours,

MERRILL LYNCH, PIERCE, FENNER & SMITH

   INCORPORATED

 COWEN AND COMPANY, LLC

EVERCORE GROUP L.L.C.

 As Representatives of the several
underwriters

 [SIGNATURE PAGES FOLLOW]

MERRILL LYNCH, PIERCE, FENNER & SMITH
                             INCORPORATED

By:

/s/ Anurag Jindal

 Name: Anurag Jindal

 Title: Managing
Director

COWEN AND COMPANY, LLC

By:

/s/ Bill Follis

 Name: Bill Follis

 Title: Managing
Director

EVERCORE GROUP L.L.C.

By:

/s/ Maren Winnick

 Name: Maren Winnick

 Title: Managing
Director

As representatives of the several underwriters.

[Signature Page to Acceleration Request Letter]