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SEC Company Response from Prelude Therapeutics (PRLD) — Dec 15, 2025

Prelude Therapeutics Inc
Date: Dec. 15, 2025 · CIK: 0001678660 · Accession: 0000929638-25-004602

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File numbers found in text: 333-292048

Date
December 15, 2025
Author
Krishna Vaddi, Ph.D.
Form
CORRESP
Company
Prelude Therapeutics Inc

Letter

Re:

Prelude Therapeutics Inc. 175 Innovation Boulevard Wilmington, Delaware 19805

December 15, 2025

VIA EDGAR TRANSMISSION

Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Alan Campbell, Esq.

Prelude Therapeutics Inc. Registration Statement on Form S-3 Filed December 10, 2025 File No. 333-292048

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Prelude Therapeutics Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-292048), so that such registration statement may become effective at 4:00 p.m. (Washington, D.C. time) on December 16, 2025 or as soon as practicable thereafter.

PRELUDE THERAPEUTICS INC.

By:

/s/ Krishna Vaddi, Ph.D.

Name:

Krishna Vaddi, Ph.D.

Title:

Chief Executive Officer

Show Raw Text
CORRESP
 1
 filename1.htm

 Prelude Therapeutics Inc.
 175 Innovation Boulevard
 Wilmington, Delaware 19805

 December 15, 2025

 VIA EDGAR TRANSMISSION

 Securities and Exchange Commission
 Division of Corporation Finance
 100 F Street, N.E.
 Washington, D.C. 20549
 Attention: Alan Campbell, Esq.

 Re:

 Prelude Therapeutics Inc.
 Registration Statement on Form S-3
 Filed December 10, 2025
 File No. 333-292048

 Ladies and Gentlemen:

 Pursuant to Rule 461 under the Securities Act of 1933, as amended, Prelude
 Therapeutics Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-292048), so that such registration statement may become effective at 4:00 p.m. (Washington, D.C. time) on December
 16, 2025 or as soon as practicable thereafter.

 PRELUDE THERAPEUTICS INC.

 By:

 /s/ Krishna Vaddi, Ph.D.

 Name:

 Krishna Vaddi, Ph.D.

 Title:

 Chief Executive Officer