SecProbe.io

CORRESP
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SENESTECH, INC.

December 5, 2016

VIA EDGAR

United States Securities and Exchange Commission (the “Commission”)
 Division of Corporation Finance
 100 F. Street, N.E.
 Mail Stop 3561
 Washington, D.C. 20549

    Attn.:
    Ms. Anne Nguyen Parker Assistant Director

                                                                  Office of Transportation and Leisure

        Re: SenesTech, Inc. (the “Company”)

        Registration Statement on Form S-1, as amended

        File No. 333-213736

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities
Act of 1933, as amended, the undersigned respectfully requests that the effective date for the Registration Statement referred
to above be accelerated so that it will be declared effective at 4:30 p.m., Eastern time on December 7, 2016, or as soon thereafter
as is practicable.

The Company hereby acknowledges that:

 · should the Commission or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose
the Commission from taking any action with respect to the filing;

 · the action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does
not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and

 · the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by
the Commission or any person under the federal securities laws of the United States.

        Very truly yours,

        SENESTECH, INC.

        By:

    /s/ Loretta P. Mayer Ph.D.

        Name:

    Loretta P. Mayer Ph.D.

    Title:
    Chief Executive Officer