SEC Company Response from SPRUCE BIOSCIENCES, (SPRB) — Nov 24, 2025
SPRUCE BIOSCIENCES, INC.
Date: Nov. 24, 2025 · CIK: 0001683553 · Accession: 0001193125-25-293651
AI Filing Summary & Sentiment
Reasoning
File numbers found in text: 333-291153
Letter
RE: Spruce Biosciences, Inc. Registration Statement on Form S-3 (File No. 333-291153) Request for Acceleration of Effective Date Ladies and Gentlemen: Spruce Biosciences, Inc. (the “ Registrant ”) hereby requests that the U.S. Securities and Exchange Commission (the “ Commission ”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-291153) (the “ Registration Statement ”) to become effective on Wednesday, November 26, 2025, at 4:30 p.m., Eastern Time, or as soon thereafter as is practicable or at such later time as the Registrant may orally request via telephone call to the staff of the Commission. The Registrant hereby authorizes each of Katherine Denby and Alexander Gefter of Cooley LLP, counsel to the Registrant, to make such request on its behalf. Once the Registration Statement has been declared effective, please orally confirm that event with Katherine Denby of Cooley LLP, counsel to the Registrant, at (202) 776-2070, or in her absence, Alexander Gefter at (310) 883-6438. [Remainder of page intentionally left blank]
S PRUCE B IOSCIENCES , I NC . 611 Gateway Boulevard, Suite 740 South San Francisco, California 94080 November 24, 2025 VIA EDGAR Securities and Exchange Commission Office of Finance Division of Corporation Finance 100 F. Street N.E. Washington, D.C. 20549-3010
Very truly yours,
S PRUCE B IOSCIENCES , I NC .
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CORRESP 1 filename1.htm CORRESP S PRUCE B IOSCIENCES , I NC . 611 Gateway Boulevard, Suite 740 South San Francisco, California 94080 November 24, 2025 VIA EDGAR Securities and Exchange Commission Office of Finance Division of Corporation Finance 100 F. Street N.E. Washington, D.C. 20549-3010 RE: Spruce Biosciences, Inc. Registration Statement on Form S-3 (File No. 333-291153) Request for Acceleration of Effective Date Ladies and Gentlemen: Spruce Biosciences, Inc. (the “ Registrant ”) hereby requests that the U.S. Securities and Exchange Commission (the “ Commission ”) take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-291153) (the “ Registration Statement ”) to become effective on Wednesday, November 26, 2025, at 4:30 p.m., Eastern Time, or as soon thereafter as is practicable or at such later time as the Registrant may orally request via telephone call to the staff of the Commission. The Registrant hereby authorizes each of Katherine Denby and Alexander Gefter of Cooley LLP, counsel to the Registrant, to make such request on its behalf. Once the Registration Statement has been declared effective, please orally confirm that event with Katherine Denby of Cooley LLP, counsel to the Registrant, at (202) 776-2070, or in her absence, Alexander Gefter at (310) 883-6438. [Remainder of page intentionally left blank] Very truly yours, S PRUCE B IOSCIENCES , I NC . By: /s/ Samir Gharib Name: Samir Gharib Title: President and Chief Financial Officer cc: Katherine Denby, Cooley LLP Alexander Gefter, Cooley LLP