SecProbe.io

January 24, 2018
David A. Giljohann, Ph.D.
Chief Executive Officer
Exicure, Inc.
8045 Lamon Avenue, Suite 410
Skokie, IL 60077
Re:Exicure, Inc.
Amendment No. 1 to Registration Statement on Form S-1
Filed January 12, 2018
File No. 333-221791
Dear Dr. Giljohann:
            We have reviewed your amended registration statement and have the following comment.
            Please respond to this letter by amending your registration statement and providing the
requested information.  If you do not believe our comment applies to your facts and
circumstances or do not believe an amendment is appropriate, please tell us why in your
response.
            After reviewing any amendment to your registration statement and the information you
provide in response to the comment, we may have additional comments.
Amendment No. 1 to Registration Statement on Form S-1
General
1.With respect to each of the Affiliated Shareholders that you reference in your response,
and any current officers and directors who are selling shareholders, please expand your
response to tell us how long they have held the Exicure shares, the circumstances under
which they received them, their relationship to the issuer and the amount of shares
involved.

 FirstName LastNameDavid A. Giljohann, Ph.D.
 Comapany NameExicure, Inc.
 June 16, 2017 Page 2
 FirstName LastName
David A. Giljohann, Ph.D.
Exicure, Inc.
January 24, 2018
Page 2

            Please contact Chris Edwards at (202) 551-6761 or Suzanne Hayes at (202) 551-3675
with any questions.
Division of Corporation Finance
Office of Healthcare & Insurance
cc: Sam Zucker