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SEC Company Response from Korro Bio, Inc. (KRRO) (CIK 0001703647) (KRRO) — Sep 13, 2019

Korro Bio, Inc. (KRRO) (CIK 0001703647)
Date: Sept. 13, 2019 · CIK: 0001703647 · Accession: 0001193125-19-244532

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File numbers found in text: 333-233652

Referenced dates: August 13, 2019

Date
Sept. 13, 2019
Author
Not clearly detected
Form
CORRESP
Company
Korro Bio, Inc. (KRRO) (CIK 0001703647)

Letter

VIA EDGAR AND HAND DELIVERY Division of Corporation Finance Attention: Donald Field Sharon Blume Re: Frequency Therapeutics, Inc. | Anticipated Price Range and Share-Based Compensation | Registration Statement on Form S-1 (File No. 333-233652) September 13, 2019 Page 2

Dear Mr. Field:

On behalf of Frequency Therapeutics, Inc. (the “Company”), we submit this letter to the staff (the “Staff”) of the Division of Corporation Finance of the Securities and Exchange Commission (the “Commission”). The Company confidentially submitted a draft of the above-referenced Registration Statement (the “Registration Statement”) to the Commission on July 19, 2019, resubmitted the Registration Statement to the Commission on August 22, 2019, and subsequently filed the Registration Statement with the Commission on September 6, 2019. The purpose of this letter is to respond to an outstanding comment relating to share-based compensation that was provided to the Company in a letter from the Staff dated August 13, 2019. Because of the commercially sensitive nature of the information contained herein, this submission is accompanied by the Company’s request for confidential treatment of selected portions of this letter pursuant to Rule 83 of the Commission’s Rules on Information and Requests, 17 C.F.R. §200.83. A redacted letter has been filed on EDGAR, omitting the confidential information contained in the Letter.

For the convenience of the Staff, we are providing to the Staff copies of this letter by hand delivery. In this letter, we have recited the prior comment from the Staff in italicized, bold type and have followed the comment with the Company’s response.

3. Once you have an estimated offering price or range, please explain to us the reasons for any differences between the recent valuations of your common stock and the estimated offering price. This information will help facilitate our review of your accounting for equity issuance including stock compensation and beneficial conversion features.

Estimated Preliminary IPO Price Range

The Company supplementally advises the Staff that, while not yet reflected in the Registration Statement, based on discussions with the Company’s board of directors (the “Board”) and reflecting input from the lead underwriters (the “Underwriters”) of the Company’s proposed initial public offering of its common stock (“IPO”), if the Company were to commence marketing of the IPO today, the Company presently anticipates that the estimated price range would be approximately $[***] per share to $[***] per share (the “Preliminary IPO Price Range”), with a midpoint of approximately $[***] per share (the “Preliminary Assumed IPO Price”), before giving effect to an anticipated reverse stock split. The Company advises the Staff that the final range to be included in a pre-effective amendment to the Registration Statement will include a price range of no more than $2.00, if the maximum price is $10.00 per share or less, or 20% of the high end of the range, if the maximum price is greater than $10.00 per share, unless otherwise approved by the Staff.

The Company’s final range to be included in a pre-effective amendment to the Registration Statement remains under discussion between the Company and the Underwriters, and a bona fide price range will be included in an amendment to the Registration Statement prior to any distribution of the preliminary prospectus in connection with the Company’s road show.

Summary of Recent Option Grants and Common Stock Valuation

The estimated fair value of the Company’s common stock has been determined by the Board as of the date of each stock option grant or restricted stock award (“RSA”), with input from management after considering third-party valuations of the common stock, as well as the Board’s assessment of additional objective and subjective factors that it believed were relevant and which may have changed from the date of the most recent third-party valuation through the date of the grant. This valuation methodology has been applied as there has been no public market to date for the common stock of the Company. These third-party valuations were performed in accordance with the guidance outlined in the American Institute of Certified Public Accountants’ Accounting and Valuation Guide, Valuation of Privately-Held-Company Equity Securities Issued as Compensation, and were prepared using a hybrid method, which is a probability-weighted expected return method (“PWERM”) where the equity value in one or more of the scenarios is calculated using an option pricing method (“OPM”).

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED BY

FREQUENCY THERAPEUTICS, INC.

September 13, 2019

Page 3

The Company’s most recent third-party valuations, which were used, in part, by the Board to determine the fair value of the Company’s common stock as of the grant date of each option and/or restricted stock award, considered a combination of the following three future-event scenarios: an IPO scenario, a sale scenario, and a liquidation scenario. The equity value of the Company in the IPO scenario and the sale scenario was determined using market approaches. The IPO scenario assumed that all shares of preferred stock would convert into shares of common stock and would no longer have the liquidation preferences and preferential rights attributable to the preferred stock as compared to the common stock prior to the IPO. Each valuation probability-weighted the future-event scenarios based on the Company’s assessment of its development pipeline and market conditions at that time. For the IPO scenario and the sale scenario, the Company then applied a discount for lack of marketability (“DLOM”), each determined by a put option analysis that considered the timing of each future-event scenario.

Since July 1, 2018, equity awards were granted as follows at the exercise or sale price that the Board determined to be the fair value per share of the Company’s common stock on that date:

Grant Date

Type

of

award

Number of Shares Subject to Award Granted

Per Share Exercise Price of Options or Sale Price for RSAs

Fair Value per Share of Common Stock on Grant Date

December 5, 2018

Options

315,000

$ 0.26

$ 0.26

December 5, 2018

RSAs

50,000

$ 0.26

$ 0.26

April 17, 2019

Options

15,995,329

$ 0.50

$ 0.50

May 20, 2019

Options

1,000,000

$ 0.50

$ 0.50

August 2, 2019

Options

1,215,000

$ 1.11

$ 1.11

August 18, 2019

Options

1,250,000

$ 1.11

$ 1.11

September 11, 2019

Options

850,000

$ 1.58

$ 1.58

The Board’s determination of each fair value was based, in part, on the results of a third-party valuation of the Company’s common stock performed on October 31, 2018 (the “October 31, 2018 Valuation”), March 31, 2019 (the “March 31, 2019 Valuation”), July 19, 2019 (the “July 19, 2019 Valuation”), and September 6, 2019 (the “September 6, 2019 Valuation”).

December 5, 2018 Option and Restricted Stock Grants. The Board determined that the fair value of the Company’s common stock was $0.26 per share as of December 5, 2018 based on input from management, the objective and subjective factors that it believed were relevant and the results of the October 31, 2018 Valuation. The October 31, 2018 Valuation was prepared taking into account the sale of shares of the Company’s Series B preferred stock to new and existing investors on October 17, 2018, at a price of $0.92 per share for total consideration of $40.0 million. In the October 31, 2018 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering three scenarios in a PWERM framework and using the OPM to allocate value in one of the scenarios. The scenarios

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED BY

FREQUENCY THERAPEUTICS, INC.

September 13, 2019

Page 4

included: a trade-sale scenario predicated on the Series B financing that transpired prior to the valuation date, an IPO scenario with reference to the arms’ length capital transaction, and a liquidation scenario. Under the hybrid method, the per share value calculated under the three scenarios are weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a DLOM is applied. The October 31, 2018 Valuation (i) assigned a 75% probability of occurrence to the trade-sale scenario, with a 71% volatility rate and a 1.9-year weighted average estimated term applied within the OPM, then reflected a DLOM of 35%; and (ii) assigned a 5% probability of occurrence to the IPO scenario, with a 30% discount rate and a 1.0-year estimated term to an IPO event, then reflected a DLOM of 15%. The liquidation scenario was weighted at 20% with no value allocated to the common stock for this scenario.

April 17, 2019 and May 20, 2019 Option Grants. The Board determined that the fair value of the Company’s common stock was $0.50 per share as of April 17, 2019 and May 20, 2019 based on input from management, the objective and subjective factors that it believed were relevant, and the results of the March 31, 2019 Valuation. In the March 31, 2019 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering three scenarios in a PWERM framework and using the OPM to allocate value in one of the scenarios. The scenarios included: a trade-sale scenario predicated on a projected future M&A transaction, an IPO scenario with reference to guideline IPO transactions, and a liquidation scenario. Under the hybrid method, the per share value calculated under the three scenarios are weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a DLOM is applied. The March 31, 2019 Valuation (i) assigned a 70% probability of occurrence to the trade-sale scenario, with a 79% volatility rate and a 1.9-year weighted average estimated term applied within the OPM, then reflected a DLOM of 30%; and (ii) assigned a 20% probability of occurrence to the IPO scenario, with a 30% discount rate and a 0.7-year estimated term to an IPO event, then reflected a DLOM of 12.5%. The liquidation scenario was weighted at 10% with no value allocated to the common stock for this scenario. The March 31, 2019 Valuation also took into consideration clinical data from the unblinding of the Company’s Phase 1 clinical trial for its primary product candidate, FX-322, in late January 2019 as well as the signing of a letter of intent on March 28, 2019 with Astellas Pharma, Inc. (“Astellas”) for a corporate collaboration centered around FX-322. Further, it also reflects that the Company was actively seeking a lead investor for its Series C preferred stock crossover financing, did not execute a term sheet until May 21, 2019, and did not fill out the financing syndicate until some time thereafter. The closing of this crossover financing was contingent on the closing of the corporate partnership with Astellas.

August 2, 2019 and August 18, 2019 Option Grants. The Board determined that the fair value of the Company’s common stock was $1.11 per share as of August 2, 2019 and August 18, 2019 based on input from management, the objective and subjective factors that it believed were relevant and the results of the July 19, 2019 Valuation. The July 19, 2019 Valuation was prepared taking into account the sale of shares of the Company’s Series C preferred stock to new and existing investors on July 17, 2019 at a price of $1.57 per share for total consideration of $62.0 million. In the July 19, 2019 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering two scenarios in a PWERM framework and using the OPM to allocate value in one of the scenarios. The scenarios included: a trade-sale scenario predicated on the Company’s Series C financing and an IPO scenario with reference to guideline IPO transactions. Under the hybrid method, the per share value calculated under the two scenarios are weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED BY

FREQUENCY THERAPEUTICS, INC.

September 13, 2019

Page 5

DLOM is applied. The July 19, 2019 Valuation (i) assigned a 40% probability of occurrence to the trade-sale scenario, with a 79% volatility rate and a 1.5-year weighted average estimated term applied within the OPM, then reflected a DLOM of 30%; and (ii) assigned a 60% probability of occurrence to the IPO scenario, with a 25% discount rate and a 0.2-year estimated term to an IPO event, then reflected a DLOM of 10%. The July 19, 2019 Valuation also took into consideration the execution of the corporate collaboration with Astellas on July 17, 2019 and the confidential submission of the Registration Statement on July 19, 2019.

September 11, 2019 Option Grants. The Board determined that the fair value of the Company’s common stock was $1.58 per share as of September 11, 2019 based on input from management, the objective and subjective factors that it believed were relevant and the results of the September 6, 2019 Valuation. The September 6, 2019 Valuation was prepared taking into account the sale of shares of the Company’s Series C preferred stock to new and existing investors on July 17, 2019 at a price of $1.57 per share for total consideration of $62.0 million. In the September 6, 2019 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering two scenarios in a PWERM framework and using the OPM to allocate value in one of the scenarios. The scenarios included: a trade-sale scenario predicated on the Company’s Series C financing and an IPO scenario with reference to guideline IPO transactions. Under the hybrid method, the per share value calculated under the two scenarios are weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a DLOM is applied. The September 6, 2019 Valuation (i) assigned a 15% probability of occurrence to the trade-sale scenario, with a 79% volatility rate and a 1.5-year weighted average estimated term applied within the OPM, then reflected a DLOM of 30%; and (ii) assigned a 85% probability of occurrence to the IPO scenario, with a 25% discount rate and a 0.24-year estimated term to an IPO event, then reflected a DLOM of 2.5%. The September 6, 2019 Valuation also took into consideration the execu

Show Raw Text
CORRESP
1
filename1.htm

CORRESP

 53rd at Third

 885 Third Avenue

New York, New York 10022-4834

 Tel: +1.212.906.1200

Fax: +1.212.751.4864

 www.lw.com

 FIRM / AFFILIATE OFFICES

 FOIA CONFIDENTIAL TREATMENT REQUEST UNDER 17 C.F.R. §200.83

 The entity requesting confidential treatment is:

 Frequency Therapeutics, Inc.

19 Presidential Way, 2nd Floor

Woburn, MA 01801

 Beijing

 Boston

Brussels

 Century City

Chicago

 Dubai

Düsseldorf

 Frankfurt

Hamburg

 Hong Kong

Houston

 London

Los Angeles

 Madrid

Milan

 Moscow

 Munich

New York

 Orange County

Paris

 Riyadh

San Diego

 San Francisco

Seoul

 Shanghai

Silicon Valley

 Singapore

Tokyo

 Washington, D.C.

 Certain confidential information in this letter has been omitted and provided separately to the Securities and Exchange
Commission. Confidential treatment has been requested by Frequency Therapeutics, Inc. with respect to the omitted portions, which are identified in this letter by the mark “[***].”

September 13, 2019

 VIA EDGAR AND HAND DELIVERY

 CONFIDENTIAL

 U.S. Securities and
Exchange Commission

 Division of Corporation Finance

 100 F
Street, N.E.

 Mail Stop 4720

 Washington, D.C. 20549

Attention:   Donald Field

Dietrich King

Andi Carpenter

Sharon Blume

Re: Frequency Therapeutics, Inc. | Anticipated Price Range and Share-Based Compensation | Registration Statement on Form S-1 (File No. 333-233652)

 September 13, 2019

Page 2

 Dear Mr. Field:

On behalf of Frequency Therapeutics, Inc. (the “Company”), we submit this letter to the staff (the
“Staff”) of the Division of Corporation Finance of the Securities and Exchange Commission (the “Commission”). The Company confidentially submitted a draft of the above-referenced Registration Statement
(the “Registration Statement”) to the Commission on July 19, 2019, resubmitted the Registration Statement to the Commission on August 22, 2019, and subsequently filed the Registration Statement with the Commission
on September 6, 2019. The purpose of this letter is to respond to an outstanding comment relating to share-based compensation that was provided to the Company in a letter from the Staff dated August 13, 2019. Because of the commercially
sensitive nature of the information contained herein, this submission is accompanied by the Company’s request for confidential treatment of selected portions of this letter pursuant to Rule 83 of the Commission’s Rules on Information and
Requests, 17 C.F.R. §200.83. A redacted letter has been filed on EDGAR, omitting the confidential information contained in the Letter.

For the convenience of the Staff, we are providing to the Staff copies of this letter by hand delivery. In this letter, we have recited the
prior comment from the Staff in italicized, bold type and have followed the comment with the Company’s response.

3.
 Once you have an estimated offering price or range, please explain to us the reasons for any differences
between the recent valuations of your common stock and the estimated offering price. This information will help facilitate our review of your accounting for equity issuance including stock compensation and beneficial conversion features.

 Estimated Preliminary IPO Price Range

The Company supplementally advises the Staff that, while not yet reflected in the Registration Statement, based on discussions with the
Company’s board of directors (the “Board”) and reflecting input from the lead underwriters (the “Underwriters”) of the Company’s proposed initial public offering of its common stock
(“IPO”), if the Company were to commence marketing of the IPO today, the Company presently anticipates that the estimated price range would be approximately $[***] per share to $[***] per share (the “Preliminary
IPO Price Range”), with a midpoint of approximately $[***] per share (the “Preliminary Assumed IPO Price”), before giving effect to an anticipated reverse stock split. The Company advises the Staff that the final
range to be included in a pre-effective amendment to the Registration Statement will include a price range of no more than $2.00, if the maximum price is $10.00 per share or less, or 20% of the high end of the
range, if the maximum price is greater than $10.00 per share, unless otherwise approved by the Staff.

 The Company’s final range to
be included in a pre-effective amendment to the Registration Statement remains under discussion between the Company and the Underwriters, and a bona fide price range will be included in an amendment to the
Registration Statement prior to any distribution of the preliminary prospectus in connection with the Company’s road show.

 Summary of Recent
Option Grants and Common Stock Valuation

 The estimated fair value of the Company’s common stock has been determined by the
Board as of the date of each stock option grant or restricted stock award (“RSA”), with input from management after considering third-party valuations of the common stock, as well as the Board’s assessment of additional
objective and subjective factors that it believed were relevant and which may have changed from the date of the most recent third-party valuation through the date of the grant. This valuation methodology has been applied as there has been no public
market to date for the common stock of the Company. These third-party valuations were performed in accordance with the guidance outlined in the American Institute of Certified Public Accountants’ Accounting and Valuation Guide, Valuation of
Privately-Held-Company Equity Securities Issued as Compensation, and were prepared using a hybrid method, which is a probability-weighted expected return method (“PWERM”) where the equity value in one or more of the
scenarios is calculated using an option pricing method (“OPM”).

 CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED BY

 FREQUENCY THERAPEUTICS, INC.

 September 13, 2019

Page 3

 The Company’s most recent third-party valuations, which were used, in part, by the Board to determine
the fair value of the Company’s common stock as of the grant date of each option and/or restricted stock award, considered a combination of the following three future-event scenarios: an IPO scenario, a sale scenario, and a liquidation
scenario. The equity value of the Company in the IPO scenario and the sale scenario was determined using market approaches. The IPO scenario assumed that all shares of preferred stock would convert into shares of common stock and would no longer
have the liquidation preferences and preferential rights attributable to the preferred stock as compared to the common stock prior to the IPO. Each valuation probability-weighted the future-event scenarios based on the Company’s assessment of
its development pipeline and market conditions at that time. For the IPO scenario and the sale scenario, the Company then applied a discount for lack of marketability (“DLOM”), each determined by a put option analysis that
considered the timing of each future-event scenario.

 Since July 1, 2018, equity awards were granted as follows at the exercise or
sale price that the Board determined to be the fair value per share of the Company’s common stock on that date:

Grant Date

 Type

of

 award

Number of
Shares Subject
to Award
Granted

Per Share Exercise
Price of Options or
Sale Price for RSAs

Fair Value
per
Share of
Common
Stock on
Grant Date

 December 5, 2018

Options

315,000

$
0.26

$
0.26

 December 5, 2018

RSAs

50,000

$
0.26

$
0.26

 April 17, 2019

Options

15,995,329

$
0.50

$
0.50

 May 20, 2019

Options

1,000,000

$
0.50

$
0.50

 August 2, 2019

Options

1,215,000

$
1.11

$
1.11

 August 18, 2019

Options

1,250,000

$
1.11

$
1.11

 September 11, 2019

Options

850,000

$
1.58

$
1.58

 The Board’s determination of each fair value was based, in part, on the results of a third-party
valuation of the Company’s common stock performed on October 31, 2018 (the “October 31, 2018 Valuation”), March 31, 2019 (the
“March 31, 2019 Valuation”), July 19, 2019 (the “July 19, 2019 Valuation”), and September 6, 2019 (the
“September 6, 2019 Valuation”).

December 5, 2018 Option and Restricted Stock Grants. The Board determined that the fair value
of the Company’s common stock was $0.26 per share as of December 5, 2018 based on input from management, the objective and subjective factors that it believed were relevant and the results of the October 31, 2018 Valuation. The
October 31, 2018 Valuation was prepared taking into account the sale of shares of the Company’s Series B preferred stock to new and existing investors on October 17, 2018, at a price of $0.92 per share for total consideration of
$40.0 million. In the October 31, 2018 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering three scenarios in a PWERM framework and using the OPM to allocate value in one of the
scenarios. The scenarios

 CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED BY

 FREQUENCY THERAPEUTICS, INC.

 September 13, 2019

Page 4

 included: a trade-sale scenario predicated on the Series B financing that transpired prior to the valuation date, an IPO
scenario with reference to the arms’ length capital transaction, and a liquidation scenario. Under the hybrid method, the per share value calculated under the three scenarios are weighted based on expected exit outcomes and the quality of the
information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a DLOM is applied. The October 31, 2018 Valuation (i) assigned a 75% probability of occurrence to the
trade-sale scenario, with a 71% volatility rate and a 1.9-year weighted average estimated term applied within the OPM, then reflected a DLOM of 35%; and (ii) assigned a 5% probability of occurrence to the
IPO scenario, with a 30% discount rate and a 1.0-year estimated term to an IPO event, then reflected a DLOM of 15%. The liquidation scenario was weighted at 20% with no value allocated to the common stock for
this scenario.

 April 17, 2019 and May 20, 2019 Option
Grants. The Board determined that the fair value of the Company’s common stock was $0.50 per share as of April 17, 2019 and May 20, 2019 based on input from management, the objective and subjective factors that it believed
were relevant, and the results of the March 31, 2019 Valuation. In the March 31, 2019 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering three scenarios in a PWERM framework and using
the OPM to allocate value in one of the scenarios. The scenarios included: a trade-sale scenario predicated on a projected future M&A transaction, an IPO scenario with reference to guideline IPO transactions, and a liquidation scenario. Under
the hybrid method, the per share value calculated under the three scenarios are weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share
of the common stock before a DLOM is applied. The March 31, 2019 Valuation (i) assigned a 70% probability of occurrence to the trade-sale scenario, with a 79% volatility rate and a 1.9-year weighted
average estimated term applied within the OPM, then reflected a DLOM of 30%; and (ii) assigned a 20% probability of occurrence to the IPO scenario, with a 30% discount rate and a 0.7-year estimated term
to an IPO event, then reflected a DLOM of 12.5%. The liquidation scenario was weighted at 10% with no value allocated to the common stock for this scenario. The March 31, 2019 Valuation also took into consideration clinical data from the
unblinding of the Company’s Phase 1 clinical trial for its primary product candidate, FX-322, in late January 2019 as well as the signing of a letter of intent on March 28, 2019 with Astellas Pharma,
Inc. (“Astellas”) for a corporate collaboration centered around FX-322. Further, it also reflects that the Company was actively seeking a lead investor for its Series C preferred stock
crossover financing, did not execute a term sheet until May 21, 2019, and did not fill out the financing syndicate until some time thereafter. The closing of this crossover financing was contingent on the closing of the corporate partnership
with Astellas.

 August 2, 2019 and August 18, 2019 Option Grants. The Board determined that
the fair value of the Company’s common stock was $1.11 per share as of August 2, 2019 and August 18, 2019 based on input from management, the objective and subjective factors that it believed were relevant and the results of the
July 19, 2019 Valuation. The July 19, 2019 Valuation was prepared taking into account the sale of shares of the Company’s Series C preferred stock to new and existing investors on July 17, 2019 at a price of $1.57 per share for
total consideration of $62.0 million. In the July 19, 2019 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering two scenarios in a PWERM framework and using the OPM to allocate value in
one of the scenarios. The scenarios included: a trade-sale scenario predicated on the Company’s Series C financing and an IPO scenario with reference to guideline IPO transactions. Under the hybrid method, the per share value calculated under
the two scenarios are weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a

 CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED BY

 FREQUENCY THERAPEUTICS, INC.

 September 13, 2019

Page 5

 DLOM is applied. The July 19, 2019 Valuation (i) assigned a 40% probability of occurrence to the trade-sale
scenario, with a 79% volatility rate and a 1.5-year weighted average estimated term applied within the OPM, then reflected a DLOM of 30%; and (ii) assigned a 60% probability of occurrence to the IPO
scenario, with a 25% discount rate and a 0.2-year estimated term to an IPO event, then reflected a DLOM of 10%. The July 19, 2019 Valuation also took into consideration the execution of the corporate
collaboration with Astellas on July 17, 2019 and the confidential submission of the Registration Statement on July 19, 2019.

September 11, 2019 Option Grants. The Board determined that the fair value of the
Company’s common stock was $1.58 per share as of September 11, 2019 based on input from management, the objective and subjective factors that it believed were relevant and the results of the September 6, 2019 Valuation. The
September 6, 2019 Valuation was prepared taking into account the sale of shares of the Company’s Series C preferred stock to new and existing investors on July 17, 2019 at a price of $1.57 per share for total consideration of
$62.0 million. In the September 6, 2019 Valuation, the independent third-party valuation specialist used a hybrid back-solve method considering two scenarios in a PWERM framework and using the OPM to allocate value in one of the scenarios.
The scenarios included: a trade-sale scenario predicated on the Company’s Series C financing and an IPO scenario with reference to guideline IPO transactions. Under the hybrid method, the per share value calculated under the two scenarios are
weighted based on expected exit outcomes and the quality of the information specific to each allocation methodology to arrive at a final estimated fair value per share of the common stock before a DLOM is applied. The September 6, 2019
Valuation (i) assigned a 15% probability of occurrence to the trade-sale scenario, with a 79% volatility rate and a 1.5-year weighted average estimated term applied within the OPM, then reflected a DLOM
of 30%; and (ii) assigned a 85% probability of occurrence to the IPO scenario, with a 25% discount rate and a 0.24-year estimated term to an IPO event, then reflected a DLOM of 2.5%. The September 6,
2019 Valuation also took into consideration the execu