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UPLOAD Filing

NuCana plc
Date: April 24, 2025 · CIK: 0001709626 · Accession: 0000000000-25-004385

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File numbers found in text: 333-286716

Date
April 24, 2025
Author
Division of
Form
UPLOAD
Company
NuCana plc

Letter

Re: NuCana plc Registration Statement on Form F-1 Filed April 24, 2025 File No. 333-286716 Dear Hugh S. Griffith:

April 24, 2025

Hugh S. Griffith Chief Executive Officer NuCana plc 3 Lochside Way Edinburgh, EH12 9DT United Kingdom

We have reviewed your amended registration statement and have the following comments.

Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe a comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response.

After reviewing any amendment to your registration statement and the information you provide in response to this letter, we may have additional comments. Unless we note otherwise, any references to prior comments are to comments in our April 17, 2025 letter.

Registration Statement on Form F-1 Cover Page

1. Please revise your cover page to disclose the date your best efforts offering will terminate. Refer to Item 501(b)(8)(iii) of Regulation S-K for guidance. 2. We note your response to prior comment 2 and your revised disclosure stating that "Mandatory Nominal Exercise Price" is "the nominal value per ordinary share." We reissue our comment in part. Please clearly disclose the dollar value of the Mandatory Nominal Exercise Price. April 24, 2025 Page 2 Risk Factors Risks Related to This Offering This offering may cause the price of our ADSs to decline and fall below the minimum bid price requirement..., page 11

3. We note your response to prior comment 4 and your revised disclosure on page 11 stating that if the closing price for your ADSs falls below $1.00 for a 30 consecutive trading day period and you are unable to regain compliance with the bid price requirement of the Nasdaq Listing Rules, you may be delisted from the Nasdaq Capital Market unless you "change the ratio of [y]our ADSs to ordinary shares[.]" We reissue our comment in part. Please revise your disclosure to clarify whether you have plans to seek shareholder approval for a reverse stock split or have plans to increase the number of ordinary shares represented by your ADSs, please disclose such plans in this registration statement, including the proposed ratio, if known.

Please contact Joshua Gorsky at 202-551-7836 or Tim Buchmiller at 202-551-3635 with any other questions.

Sincerely,
Division of
Corporation Finance
Office of Life
Sciences
cc: John T. Rudy, Esq.

Show Raw Text
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<TEXT>
 April 24, 2025

Hugh S. Griffith
Chief Executive Officer
NuCana plc
3 Lochside Way
Edinburgh, EH12 9DT
United Kingdom

 Re: NuCana plc
 Registration Statement on Form F-1
 Filed April 24, 2025
 File No. 333-286716
Dear Hugh S. Griffith:

 We have reviewed your amended registration statement and have the
following
comments.

 Please respond to this letter by amending your registration statement
and providing
the requested information. If you do not believe a comment applies to your
facts and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

 After reviewing any amendment to your registration statement and the
information
you provide in response to this letter, we may have additional comments. Unless
we note
otherwise, any references to prior comments are to comments in our April 17,
2025 letter.

Registration Statement on Form F-1
Cover Page

1. Please revise your cover page to disclose the date your best efforts
offering will
 terminate. Refer to Item 501(b)(8)(iii) of Regulation S-K for guidance.
2. We note your response to prior comment 2 and your revised disclosure
stating that
 "Mandatory Nominal Exercise Price" is "the nominal value per ordinary
share." We
 reissue our comment in part. Please clearly disclose the dollar value of
the Mandatory
 Nominal Exercise Price.
 April 24, 2025
Page 2
Risk Factors
Risks Related to This Offering
This offering may cause the price of our ADSs to decline and fall below the
minimum bid
price requirement..., page 11

3. We note your response to prior comment 4 and your revised disclosure on
page 11
 stating that if the closing price for your ADSs falls below $1.00 for a
30 consecutive
 trading day period and you are unable to regain compliance with the bid
price
 requirement of the Nasdaq Listing Rules, you may be delisted from the
Nasdaq
 Capital Market unless you "change the ratio of [y]our ADSs to ordinary
shares[.]" We
 reissue our comment in part. Please revise your disclosure to clarify
whether you have
 plans to seek shareholder approval for a reverse stock split or have
plans to increase
 the number of ordinary shares represented by your ADSs, please disclose
such plans
 in this registration statement, including the proposed ratio, if known.

 Please contact Joshua Gorsky at 202-551-7836 or Tim Buchmiller at
202-551-3635
with any other questions.

 Sincerely,

 Division of
Corporation Finance
 Office of Life
Sciences
cc: John T. Rudy, Esq.
</TEXT>
</DOCUMENT>