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CORRESP Filing

NuCana plc
Date: April 29, 2025 · CIK: 0001709626 · Accession: 0001193125-25-103256

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File numbers found in text: 333-286716

Date
April 29, 2025
Author
NUCANA PLC
Form
CORRESP
Company
NuCana plc

Letter

Re: NuCana plc Registration Statement on Form F-1, as amended Filed April 29, 2025 File No. 333-286716 (the “Registration Statement”) Acceleration Request Ladies and Gentlemen: In accordance with Rule 461 of the Rules and Regulations promulgated under the Securities Act of 1933, as amended, NuCana plc (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Wednesday, April 30, 2025, at 5:00 p.m., Eastern Time, or as soon as thereafter practicable. The cooperation of the staff in meeting the timetable described above is very much appreciated. Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617) 348-3050 with any questions regarding this request.

NUCANA PLC 3 Lochside Way Edinburgh, EH12 9DT United Kingdom April 29, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Joshua Gorsky and Tim Buchmiller

Very truly yours,
NUCANA PLC

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CORRESP
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 CORRESP

 NUCANA PLC
 3 Lochside Way
 Edinburgh, EH12 9DT
 United Kingdom April 29, 2025
 VIA EDGAR U.S. Securities and Exchange Commission
 Division of Corporation Finance Office of Life Sciences
 100 F Street, N.E. Washington, D.C. 20549 Attention: Joshua
Gorsky and Tim Buchmiller

 Re:
 NuCana plc
 Registration Statement on Form F-1, as amended
 Filed April 29, 2025
 File No. 333-286716 (the “Registration Statement”)
 Acceleration Request Ladies and
Gentlemen: In accordance with Rule 461 of the Rules and Regulations promulgated under the Securities Act of 1933, as amended, NuCana plc (the
“Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Wednesday, April 30, 2025, at 5:00 p.m., Eastern Time, or as
soon as thereafter practicable. The cooperation of the staff in meeting the timetable described above is very much appreciated.
 Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617)
 348-3050 with any questions regarding this request.

 Very truly yours,

 NUCANA PLC

 /s/ Hugh S. Griffith

 Hugh S. Griffith
 Chief Executive Officer

 cc:
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
 John T. Rudy, Esq.