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CORRESP Filing

NuCana plc
Date: May 1, 2025 · CIK: 0001709626 · Accession: 0001193125-25-110311

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File numbers found in text: 333-286716

Date
May 1, 2025
Author
NUCANA PLC
Form
CORRESP
Company
NuCana plc

Letter

Re: NuCana plc Registration Statement on Form F-1, as amended Filed April 29, 2025 File No. 333-286716 (the “Registration Statement”) Withdrawal of Acceleration Request Ladies and Gentlemen: Reference is made to our letter, filed as correspondence via EDGAR on April 29, 2025, in which we requested the acceleration of the effective date of the above-referenced Registration Statement for Wednesday, April 30, 2025 at 5:00 p.m., Eastern Time, in accordance with Rule 461 under the Securities Act of 1933, as amended. We are no longer requesting that such Registration Statement be declared effective at this time and we hereby formally withdraw our request for acceleration of the effective date. Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617) 348-3050 with any questions regarding this request.

NUCANA PLC 3 Lochside Way Edinburgh, EH12 9DT United Kingdom May 1, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Joshua Gorsky and Tim Buchmiller

Very truly yours,
NUCANA PLC

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CORRESP
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 filename1.htm

 CORRESP

 NUCANA PLC
 3 Lochside Way
 Edinburgh, EH12 9DT
 United Kingdom May 1, 2025
 VIA EDGAR U.S. Securities and Exchange Commission
 Division of Corporation Finance Office of Life Sciences
 100 F Street, N.E. Washington, D.C. 20549 Attention: Joshua
Gorsky and Tim Buchmiller

 Re:
 NuCana plc
 Registration Statement on Form F-1, as amended
 Filed April 29, 2025
 File No. 333-286716 (the “Registration Statement”)
 Withdrawal of Acceleration Request
 Ladies and Gentlemen: Reference is made to our letter, filed as
correspondence via EDGAR on April 29, 2025, in which we requested the acceleration of the effective date of the above-referenced Registration Statement for Wednesday, April 30, 2025 at 5:00 p.m., Eastern Time, in accordance with Rule 461
under the Securities Act of 1933, as amended. We are no longer requesting that such Registration Statement be declared effective at this time and we hereby formally withdraw our request for acceleration of the effective date.
 Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617)
 348-3050 with any questions regarding this request.

 Very truly yours,

 NUCANA PLC

 /s/ Hugh S. Griffith

 Hugh S. Griffith Chief Executive
Officer

 cc:
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
 John T. Rudy, Esq.