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      ADVENT TECHNOLOGIES HOLDINGS, INC.

      200 Clarendon Street

      Boston, MA 02116

      April 26, 2022

      VIA EDGAR

      U.S. Securities and Exchange Commission

      Division of Corporation Finance

      100 F Street, N.E.

      Washington, D.C. 20549

            Re:

            Advent Technologies Holdings, Inc.

                Registration Statement on Form S-1

                File Number 333-264421

      Ladies and Gentlemen:

      Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Advent Technologies Holdings, Inc. hereby respectfully
        requests that the effective date of the above referenced Registration Statement on Form S-1 (File No. 333-264421) be accelerated to 4:00 p.m., Eastern Time, on Thursday, April 28, 2022, or as soon as practicable thereafter.

      Please contact Katherine Blair of Manatt, Phelps & Phillips, LLP at (310) 312-4252 with any questions you may have regarding this
        request. In addition, please notify Ms. Blair by telephone when this request for acceleration has been granted.

            Respectfully,

              ADVENT TECHNOLOGIES HOLDINGS, INC.

            By:

              /s/ James F. Coffey

            Name:

            James F. Coffey

            Title:

            Chief Operating Officer and

            General Counsel

            cc:

            Manatt, Phelps & Phillips, LLP