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CORRESP
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CORRESP

January 30, 2020

 Marc A. Rubenstein

 T +1 617 951 7826

marc.rubenstein@ropesgray.com

 BY FEDEX AND EDGAR

Securities and Exchange Commission

 Division of Corporation
Finance

 100 F Street, N.E. Washington, D.C. 20549

Attention: Tonya K. Aldave and Dietrich King

Re:
 Beam Therapeutics Inc.

 Amendment No. 1 to Registration Statement on Form S-1

 Filed January 17, 2020

 Amendment No. 2 to Registration Statement on Form S-1

 Filed January 27, 2020

 File No. 333-233985

Ladies and Gentlemen:

 On behalf of Beam Therapeutics Inc. (the
“Company”), we hereby transmit via EDGAR for filing with the Securities and Exchange Commission (the “Commission”) Amendment No. 3 (“Amendment No. 3”) to the above-referenced registration statement (the
“Registration Statement”) relating to the offering of shares of its common stock. Marked copies, which show changes from the Amendment No. 2 to the Registration Statement as filed on January 27, 2020 (“Amendment
No. 2”), are being furnished supplementally for the convenience of the staff of the Division of Corporation Finance (the “Staff”) of the Commission. The Registration Statement has been revised in response to the Staff’s
comments.

 In addition, we are providing the following responses to the comment letter from the Staff dated January 29, 2020 regarding Amendment
No. 2. To assist your review, we have presented the text of the Staff’s comments in italics below. The responses and information described below are based upon information provided to us by the Company.

Amendment No. 2 to Registration Statement on Form S-1

Dilution, page 92

1.
 Please provide us calculations supporting “Pro forma net tangible book value per share of common stock
as of September 30, 2019” of $3.24 per share and “Pro forma as adjusted net tangible book value per share of common stock after the offering” of $4.78 per share. Also,

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January 30, 2020

explain your basis for including redeemable convertible stock of $298,786 in determining “Historical net tangible book value per share of common stock at September 30, 2019.” In
addition, explain your basis for including 3,043,669 shares of unvested restricted stock that is “not issued and outstanding for accounting purposes and not included in our consolidated financial statements.” Refer us to the technical
guidance upon which you relied and revise your presentation accordingly.

 Response to Comment 1: In response to the Staff’s
comment, the Company has revised the Registration Statement on pages 92 and 93 to exclude redeemable convertible stock of $298,786 in determining “Historical net tangible book deficit per share of common stock at September 30, 2019” and to
exclude the 3,043,669 shares of unvested restricted from the calculations of “Historical net tangible book value per share of common stock as of September 30, 2019,” “Pro forma net tangible book value per share of common stock as of
September 30, 2019,” and “Pro forma as adjusted net tangible book value per share of common stock after the offering.”

 In response to the
Staff’s comment, below are the calculations supporting the revised calculation of “Historical net tangible book deficit per share”, “Pro forma net tangible book value per share of common stock as of September 30, 2019” and
“Pro forma as adjusted net tangible book value per share of common stock after the offering.”

 Historical net tangible deficit per share

 Total Assets

$
170,553

 Less: Total Liabilities

(43,832
)

 Less: Preferred Stock

$
(298,786
)

 Net Tangible Book Value

$
(172,065
)

 Common Stock outstanding as of September 30, 2019

6,903,654

(excludes 3,043,669 unvested restricted shares
)

 Historical net tangible deficit per share as of September 30, 2019

$
(24.92
)

 Proforma net tangible book value per share

 Total Assets

$
170,553

 Less: Total Liabilities

(43,832
)

 Net Tangible Book Value

$
126,721

 Common Stock outstanding as of September 30, 2019

6,903,654

(excludes 3,043,669 unvested restricted shares
)

 Preferred Stock

29,127,523

 Total Proforma common stock outstanding

36,031,177

 Proforma net tangible book value per share as of September 30, 2019

$
3.52

 Proforma as adjusted net tangible book value per share after this offering

 Total Assets

$
170,553

 Less: Total Liabilities

(43,832
)

 Offering Proceeds

89,750

 Net Tangible Book Value

$
216,471

 Common Stock outstanding as of September 30, 2019

6,903,654

(excludes 3,043,669 unvested restricted shares
)

 Preferred Stock

29,127,523

 Shares Offered

6,250,000

 Total Proforma as adjusted common stock outstanding

42,281,177

 Proforma as adjusted net tangible book value per share after this offering

$
5.12

 General

2.
 We note that your forum selection provision identifies the Court of Chancery of the State of Delaware as the
exclusive forum for certain litigation, including any “derivative action.” Please disclose whether this provision applies to actions arising under the Exchange Act. In that regard, we note that Section 27 of the Exchange Act creates
exclusive federal jurisdiction over all suits brought to enforce any duty or liability created by the Exchange Act or the rules and regulations thereunder. If this provision does not apply to actions arising under the Securities Act or Exchange Act,
please also ensure that the exclusive forum provision in the governing documents states this clearly, or tell us how you will inform investors in future filings that the provision does not apply to any actions arising under the Securities Act or
Exchange Act.

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January 30, 2020

 Response to Comment 2: The Company acknowledges the Staff’s comment and advises that the
Company’s forum selection provision as revised explicitly does not apply to claims arising under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended. In response to the Staff’s comment, the Company
has revised its amended and restated certificate of incorporation and pages 84 and 222 of the Registration Statement to clarify that this provision does not apply to claims arising under the Securities Act of 1933, as amended, or the Securities
Exchange Act of 1934, as amended. The Company undertakes to include similar disclosure in its Annual Report on Form 10-K and any other applicable future filings with the Commission.

*    *    *    *    *

Please do not hesitate to call me at 617-951-7826 or Thomas J. Danielski at 617-235-4961 with any questions or further comments you may have regarding this filing or if you wish to discuss the above responses.

Sincerely,

 /s/ Marc Rubenstein

Marc A. Rubenstein

cc:
 John Evans (Beam Therapeutics Inc.)

Thomas J. Danielski (Ropes & Gray LLP)