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CORRESP Filing

Cyclerion Therapeutics, Inc.
Date: May 13, 2025 · CIK: 0001755237 · Accession: 0001193125-25-118816

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File numbers found in text: 333-287006

Date
May 15, 2025
Author
Regina Graul, Ph.D.
Form
CORRESP
Company
Cyclerion Therapeutics, Inc.

Letter

Re: Cyclerion Therapeutics, Inc. Registration Statement on Form S-3 (File No. 333-287006) Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations of the Securities and Exchange Commission promulgated under the Securities Act of 1933, as amended, Cyclerion Therapeutics, Inc., a Massachusetts corporation (the “ Company ”), hereby requests that the effective date for the registration statement referred to above be accelerated so that it will be declared effective at 4:00 p.m. Eastern Time on May 15, 2025, or as soon as possible thereafter. The Company hereby authorizes William Michener of Ropes & Gray LLP, counsel to the Company, to orally modify or withdraw this request for acceleration. Please contact William Michener (william.michener@ropesgray.com) / telephone: (617) 951-7247 of Ropes & Gray LLP as soon as the registration statement has been declared effective. [ Signature page follows ]

Cyclerion Therapeutics, Inc. 245 First Street, 18 th Floor Cambridge, MA 02142 May 13, 2025 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549

Attention: Doris Stacey Gama

Very truly yours,
CYCLERION THERAPEUTICS, INC.

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CORRESP
 1
 filename1.htm

 CORRESP

 Cyclerion Therapeutics, Inc.
 245 First Street, 18 th Floor
 Cambridge, MA 02142 May 13,
2025 VIA EDGAR Securities and Exchange
Commission Division of Corporation Finance 100 F Street,
N.E. Washington, D.C. 20549

 Attention:
 Doris Stacey Gama

 Re:
 Cyclerion Therapeutics, Inc.
 Registration Statement on Form S-3 (File No. 333-287006)
 Request for Acceleration Ladies and
Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations of the Securities and Exchange Commission promulgated under the Securities Act of
1933, as amended, Cyclerion Therapeutics, Inc., a Massachusetts corporation (the “ Company ”), hereby requests that the effective date for the registration statement referred to above be accelerated so that it will be declared
effective at 4:00 p.m. Eastern Time on May 15, 2025, or as soon as possible thereafter. The Company hereby authorizes William Michener of Ropes & Gray LLP, counsel to the Company, to orally modify or withdraw this request for
acceleration. Please contact William Michener (william.michener@ropesgray.com) / telephone: (617) 951-7247 of
Ropes & Gray LLP as soon as the registration statement has been declared effective. [ Signature page follows ]

 Very truly yours,

 CYCLERION THERAPEUTICS, INC.

 By:

 /s/ Regina Graul

 Name:

 Regina Graul, Ph.D.

 Title:

 President and Chief Executive Officer

 [ Signature Page to
Acceleration Request ]