CORRESP Filing
Shuttle Pharmaceuticals Holdings, Inc.
Date: Feb. 13, 2026 · CIK: 0001757499 · Accession: 0001493152-26-006671
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File numbers found in text: 333-293363
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CORRESP 1 filename1.htm E.F. Hutton & Co. 745 Fifth Avenue, 34th Floor & PH New York, NY 10151 February 13, 2026 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Shuttle Pharmaceuticals Holdings, Inc. Registration Statement on Form S-1 File No. 333-293363 REQUEST FOR ACCELERATION OF EFFECTIVENESS Requested Date: Tuesday, February 17, 2026 Requested Time: 4:30 p.m., Eastern Time Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended (the "Securities Act"), we, the undersigned, as the sole placement agent for the proposed public offering on a best-efforts basis of securities of Shuttle Pharmaceuticals Holdings, Inc. (the "Company"), hereby join the Company's request that the effective date of the above-referenced Registration Statement on Form S-1, as amended, be accelerated so that it will be declared effective at 4:30 p.m., Eastern Time, on Tuesday, February 17, 2026, or as soon thereafter as possible. Pursuant to Rule 460 under the Securities Act, please be advised that we will distribute as many copies of the proposed form of preliminary prospectus as it appears to be reasonable to secure adequate distribution of the preliminary prospectus. The undersigned confirms that it has complied with and will continue to comply with the requirements of Rule 15c2-8 promulgated under the Securities Exchange Act of 1934, as amended. Very truly yours, E.F. HUTTON & CO. By: /s/ Duncan B. Swanston Name: Duncan B. Swanston Title: Supervisory Principal