CORRESP Filing
BICYCLE THERAPEUTICS PLC
Date: Aug. 12, 2025 · CIK: 0001761612 · Accession: 0001104659-25-076811
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File numbers found in text: 333-289423
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CORRESP 1 filename1.htm Bicycle Therapeutics plc Blocks A & B, Portway Building Granta Park Great Abington, Cambridge CB21 6GS United Kingdom August 12, 2025 Via Edgar United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jessica Dickerson RE: Bicycle Therapeutics plc Registration Statement on Form S-3 File No. 333-289423 Acceleration Request Requested Date: August 14, 2025 Requested Time: 4:00 p.m. Eastern Time Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Exchange Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289423) (the " Registration Statement ") to become effective at 4:00 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as is practicable. Once the Registration Statement has been declared effective, please orally confirm that event with Jaime L. Chase of Cooley LLP, counsel to the registrant, at (202) 728-7096. [ Signature page follows ] Sincerely, Bicycle Therapeutics plc By: /s/ Alethia Young Alethia Young Chief Financial Officer cc: Kevin Lee, Chief Executive Officer, Bicycle Therapeutics plc Laura A. Berezin, Cooley LLP Jaime L. Chase, Cooley LLP