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CORRESP Filing

BICYCLE THERAPEUTICS PLC
Date: Aug. 12, 2025 · CIK: 0001761612 · Accession: 0001104659-25-076811

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File numbers found in text: 333-289423

Date
August 12, 2025
Author
Bicycle Therapeutics plc
Form
CORRESP
Company
BICYCLE THERAPEUTICS PLC

Letter

Bicycle Therapeutics plc

Blocks A & B, Portway Building

Granta Park Great Abington, Cambridge CB21 6GS

United Kingdom

August 12, 2025

Via Edgar

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Jessica Dickerson

RE: Bicycle Therapeutics plc

Registration Statement on Form S-3

File No. 333-289423

Acceleration Request

Requested Date: August 14, 2025

Requested Time: 4:00 p.m. Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Exchange Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289423) (the " Registration Statement ") to become effective at 4:00 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Jaime L. Chase of Cooley LLP, counsel to the registrant, at (202) 728-7096.

[ Signature page follows ]

Sincerely,
Bicycle Therapeutics plc

Show Raw Text
CORRESP
 1
 filename1.htm

 Bicycle
Therapeutics plc

 Blocks A & B, Portway Building

 Granta Park Great Abington, Cambridge CB21 6GS

 United Kingdom

 August 12, 2025

 Via Edgar

 United States Securities and Exchange Commission

 Division of Corporation Finance

 100 F Street, N.E.

 Washington, D.C. 20549

 Attn:	Jessica Dickerson

 RE: Bicycle Therapeutics plc

 Registration Statement
on Form S-3

 File
No. 333-289423

 Acceleration Request

 Requested Date:
 August 14, 2025

 Requested Time:
 4:00 p.m. Eastern Time

 Ladies and Gentlemen:

 Pursuant to Rule 461 under the Securities Exchange
Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action
to cause the above-referenced Registration Statement on Form S-3 (File No. 333-289423) (the " Registration Statement ")
to become effective at 4:00 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as is practicable.

 Once the Registration Statement has been declared
effective, please orally confirm that event with Jaime L. Chase of Cooley LLP, counsel to the registrant, at (202) 728-7096.

 [ Signature page follows ]

 Sincerely,

 Bicycle Therapeutics plc

 By:
 /s/ Alethia Young

 Alethia Young

 Chief Financial Officer

 cc:
 Kevin Lee, Chief Executive Officer, Bicycle Therapeutics plc

 Laura A. Berezin, Cooley LLP

 Jaime L. Chase, Cooley LLP