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Correspondence 0001104659-25-124218 from Aprea Therapeutics, Inc. (APRE)

Aprea Therapeutics, Inc.
Date: Dec. 23, 2025 · CIK: 0001781983 · Accession: 0001104659-25-124218

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File numbers found in text: 333-292286

Date
December 23, 2025
Author
John Hamill
Form
CORRESP
Company
Aprea Therapeutics, Inc.

Letter

December 23, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, NE

Washington, D.C. 20549

Attention: Chris Edwards

Re: Aprea Therapeutics, Inc.

Registration Statement on Form S-3 Filed December 19, 2025 File No. 333-292286 Acceleration Request Requested Date: December 29, 2025 Requested Time: 4:00 P.M. Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Aprea Therapeutics, Inc. (the " Registrant ") hereby requests that the above-referenced Registration Statement on Form S-3 (File No. 333-292286) (the " Registration Statement ") be declared effective on the "Requested Date" at the "Requested Time" set forth above, or as soon as practicable thereafter.

We request that we be notified of the effectiveness of the Registration Statement by telephone to Patrick O'Malley of DLA Piper LLP (US) at 858.677.1471. Thank you for your assistance.

Very truly yours,
Aprea Therapeutics, Inc.

Show Raw Text
CORRESP
 1
 filename1.htm

 December 23, 2025

 VIA EDGAR

 U.S. Securities and Exchange Commission

 Division of Corporation Finance

 Office of Life Sciences

 100 F Street, NE

 Washington, D.C. 20549

 Attention: Chris Edwards

 Re:
 Aprea Therapeutics, Inc.

 Registration Statement on Form S-3
 Filed December 19, 2025
 File No. 333-292286
 Acceleration Request
 Requested Date: December 29, 2025
 Requested Time: 4:00 P.M. Eastern Time

 Ladies and Gentlemen:

 Pursuant to Rule 461 under
the Securities Act of 1933, as amended, Aprea Therapeutics, Inc. (the " Registrant ") hereby requests that
the above-referenced Registration Statement on Form S-3 (File No. 333-292286) (the " Registration Statement ")
be declared effective on the "Requested Date" at the "Requested Time" set forth above, or as soon as practicable
thereafter.

 We request that we be notified of the effectiveness
of the Registration Statement by telephone to Patrick O'Malley of DLA Piper LLP (US) at 858.677.1471. Thank you for your assistance.

 Very truly yours,

 Aprea Therapeutics, Inc.

 /s/ John Hamill

 John Hamill

 Chief Financial Officer

 cc:

 Oren Gilad (Chief Executive Officer; Aprea Therapeutics, Inc.)
 Patrick O'Malley (DLA Piper LLP (US))