Correspondence 0001213900-25-124653 from Onconetix, Inc. (ONCO)

Onconetix, Inc.
Date: Dec. 22, 2025 · CIK: 0001782107 · Accession: 0001213900-25-124653

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File numbers found in text: 333-291256

Date

November 4, 2025

Author

Karina M. Fedasz

Form

CORRESP

Company

Onconetix, Inc.

Letter

Onconetix, Inc.

E. Fifth Street, Suite 1900

Cincinnati, OH 45202

VIA EDGAR

December 22, 2025

U.S. Securities and Exchange Commission

Office of Life Sciences

Washington, D.C. 20549

Attn: Alan Campbell

Re: Onconetix, Inc.

Registration Statement on Form S-1

Initially Filed on November 4, 2025

File No. 333-291256

Ladies and Gentleman,

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Onconetix, Inc. hereby requests acceleration of effectiveness of the above referenced Registration Statement so that it will become effective at 9:00 a.m. EST on Tuesday, December 23, 2025, or as soon as thereafter practicable.

Very truly yours,
/s/
Karina M. Fedasz

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CORRESP
 1
 filename1.htm

 Onconetix,
Inc.

 201
E. Fifth Street, Suite 1900

 Cincinnati,
OH 45202

 VIA
EDGAR

 December
22, 2025

 U.S. Securities
and Exchange Commission

 Office of
Life Sciences

 Washington,
D.C. 20549

 Attn: Alan
Campbell

 Re:
 Onconetix, Inc.

 Registration Statement
 on Form S-1

 Initially Filed on
 November 4, 2025

 File
 No. 333-291256

 Ladies
and Gentleman,

 Pursuant
to Rule 461 under the Securities Act of 1933, as amended, Onconetix, Inc. hereby requests acceleration of effectiveness of the above
referenced Registration Statement so that it will become effective at 9:00 a.m. EST on Tuesday, December 23, 2025, or as soon as thereafter
practicable.

 Very truly yours,

 /s/
 Karina M. Fedasz

 By:
 Karina M. Fedasz

 Title:
 Interim Chief Executive Officer and Interim Financial Officer

 cc:
 Ellenoff Grossman & Schole LLP

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