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Correspondence 0001193125-24-026684 from Metagenomi Therapeutics, Inc. (MGX)

Metagenomi Therapeutics, Inc.
Date: Feb. 7, 2024 · CIK: 0001785279 · Accession: 0001193125-24-026684

AI Filing Summary & Sentiment

File numbers found in text: 333-276413

Referenced dates: February 6, 2024

Date
February 7, 2024
Author
Enclosures
Form
CORRESP
Company
Metagenomi Therapeutics, Inc.

Letter

VIA EDGAR AND FEDERAL EXPRESS United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Attention: Jenn Do, Angela Connell, Tyler Howes and Suzanne Hayes Metagenomi, Inc. Amendment No. 2 to Registration Statement on Form S-1 Filed February 5, 2024 File No. 333-276413

Dear Ladies and Gentlemen:

This letter is submitted on behalf of Metagenomi, Inc. (the “Company”), in response to the comments of the staff of the Division of Corporation Finance (the “Staff”) of the U.S. Securities and Exchange Commission (the “Commission”) with respect to the Company’s Registration Statement on Form S-1 filed on January 5, 2024, as amended by Amendment No. 1 to Registration Statement on Form S-1, filed on January 8, 2024, and Amendment No. 2 to Registration Statement on Form S-1, filed on February 5, 2024 (the “Registration Statement”), as set forth in the Staff’s letter, dated February 6, 2024, addressed to Brian Thomas, Ph.D. (the “Comment Letter”). The Company is concurrently publicly filing the Amendment No. 3 to the Registration Statement on Form S-1 (the “Amendment No. 3”).

For reference purposes, the text of the Comment Letter has been reproduced herein with responses below each numbered comment. For your convenience, we have italicized the reproduced Staff comments from the Comment Letter. Unless otherwise indicated, page references in the descriptions of the Staff’s comments refer to the Registration Statement, and page references in the responses refer to the Amendment No. 3. All capitalized terms used and not otherwise defined herein shall have the meanings set forth in the Amendment No. 3.

Amendment No. 2 to Registration Statement on Form S-1

Use of Proceeds, page 94

1. We note that you intend to fund continued research and development of your therapeutic portfolio including preclincial studies and advancement through preclinical proof-of-concept, and at least two IND filings for “certain” of your preclinical programs with the

proceeds from this offering. Please clarify if the continued research and development will be allocated evenly across all of your programs and if you have determined which of your preclinical programs you will fund with the proceeds from this offering. To the extent these programs are known, please also revise to disclose them in your Use of Proceeds section. If you have not determined which preclinical programs you will fund with proceeds from the offering, please explain how you will determine which programs to fund.

RESPONSE: The Company acknowledges the Staff’s comment and has revised its disclosure on pages 12 and 94 of Amendment No. 3 in response to the Staff’s comment.

If you should have any questions concerning the enclosed matters, please contact the undersigned at (212) 813-8800.

Sincerely,
Enclosures

Show Raw Text
CORRESP
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CORRESP

 Goodwin Procter LLP

 100 Northern Avenue

Boston, MA 02210

 goodwinlaw.com

+1 617 570 1000

 February 7, 2024

VIA EDGAR AND FEDERAL EXPRESS

 United States
Securities and Exchange Commission

 Division of Corporation Finance

Office of Life Sciences

 100 F. Street, N.E.

Washington, D.C. 20549

 Attention: Jenn Do, Angela Connell, Tyler
Howes and Suzanne Hayes

  Re:

Metagenomi, Inc.

Amendment No. 2 to Registration Statement on Form S-1

Filed February 5, 2024

File No. 333-276413

 Dear Ladies and Gentlemen:

This letter is submitted on behalf of Metagenomi, Inc. (the “Company”), in response to the comments of the staff of the
Division of Corporation Finance (the “Staff”) of the U.S. Securities and Exchange Commission (the “Commission”) with respect to the Company’s Registration Statement on Form
S-1 filed on January 5, 2024, as amended by Amendment No. 1 to Registration Statement on Form S-1, filed on January 8, 2024, and Amendment No. 2 to
Registration Statement on Form S-1, filed on February 5, 2024 (the “Registration Statement”), as set forth in the Staff’s letter, dated February 6, 2024, addressed to Brian
Thomas, Ph.D. (the “Comment Letter”). The Company is concurrently publicly filing the Amendment No. 3 to the Registration Statement on Form S-1 (the “Amendment
No. 3”).

 For reference purposes, the text of the Comment Letter has been reproduced herein with responses
below each numbered comment. For your convenience, we have italicized the reproduced Staff comments from the Comment Letter. Unless otherwise indicated, page references in the descriptions of the Staff’s comments refer to the Registration
Statement, and page references in the responses refer to the Amendment No. 3. All capitalized terms used and not otherwise defined herein shall have the meanings set forth in the Amendment No. 3.

Amendment No. 2 to Registration Statement on Form S-1

Use of Proceeds, page 94

1.
 We note that you intend to fund continued research and development of your therapeutic portfolio including
preclincial studies and advancement through preclinical proof-of-concept, and at least two IND filings for “certain” of your preclinical programs with the

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proceeds from this offering. Please clarify if the continued research and development will be allocated evenly across all of your programs and if you have determined which of your preclinical
programs you will fund with the proceeds from this offering. To the extent these programs are known, please also revise to disclose them in your Use of Proceeds section. If you have not determined which preclinical programs you will fund with
proceeds from the offering, please explain how you will determine which programs to fund.

 RESPONSE: The Company acknowledges the
Staff’s comment and has revised its disclosure on pages 12 and 94 of Amendment No. 3 in response to the Staff’s comment.

If you should have any questions concerning the enclosed matters, please contact the undersigned at (212) 813-8800.

Sincerely,

Enclosures

 /s/ Edwin M. O’Connor

Edwin M. O’Connor, Esq.

cc:

Brian C. Thomas, Ph.D., Metagenomi, Inc.

Mitchell S. Bloom, Esq., Goodwin Procter LLP

Justin S. Platt, Esq., Goodwin Procter LLP

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