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UPLOAD Filing

Adagene Inc.
Date: May 21, 2025 · CIK: 0001818838 · Accession: 0000000000-25-005414

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File numbers found in text: 333-287161

Date
May 21, 2025
Author
Division of
Form
UPLOAD
Company
Adagene Inc.

Letter

Re: Adagene Inc. Registration Statement on Form F-3 Filed May 9, 2025 File No. 333-287161 Dear Peter Luo:

May 21, 2025

Peter Luo Chief Executive Officer Adagene Inc. 4F, Building C14, No. 218 Xinghu Street, Suzhou Industrial Park Suzhou, Jiangsu Province, 215123 People s Republic of China

We have conducted a limited review of your registration statement and have the following comments.

Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe a comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response.

After reviewing any amendment to your registration statement and the information you provide in response to this letter, we may have additional comments.

Registration Statement on Form F-3 General

1. Please revise the first bullet of the Explanatory Note to reflect the inclusion of resale shares to be offered by selling shareholders in the base prospectus. Cover Page

2. We note that your base prospectus covers the offering of up to $200 million of ordinary shares, warrants or units to be offered by you or selling shareholders. Please revise your cover page to quantify the number of ordinary shares that may be offered by the selling shareholders. Please also revise your disclosure, where appropriate, to identify the selling shareholders and provide a brief description of the initial May 21, 2025 Page 2

transaction in which these securities were sold to the selling shareholders. Refer to Item 501 of Regulation S-K and General Instruction II.H of Form F-3 for guidance. We note that you do not appear to qualify for the omission of this information under Rule 430B(b) because the company is not primarily eligible to use Form F-3 under General Instruction I.B.1. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff.

Refer to Rules 460 and 461 regarding requests for acceleration. Please allow adequate time for us to review any amendment prior to the requested effective date of the registration statement.

Please contact Tyler Howes at 202-551-3370 or Laura Crotty at 202-551-7614 with any questions.

Sincerely,
Division of
Corporation Finance
Office of Life
Sciences
cc: Xuelin Wang, Esq.

Show Raw Text
<DOCUMENT>
<TYPE>TEXT-EXTRACT
<SEQUENCE>2
<FILENAME>filename2.txt
<TEXT>
 May 21, 2025

Peter Luo
Chief Executive Officer
Adagene Inc.
4F, Building C14, No. 218
Xinghu Street, Suzhou Industrial Park
Suzhou, Jiangsu Province, 215123
People s Republic of China

 Re: Adagene Inc.
 Registration Statement on Form F-3
 Filed May 9, 2025
 File No. 333-287161
Dear Peter Luo:

 We have conducted a limited review of your registration statement and
have the
following comments.

 Please respond to this letter by amending your registration statement
and providing
the requested information. If you do not believe a comment applies to your
facts and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

 After reviewing any amendment to your registration statement and the
information
you provide in response to this letter, we may have additional comments.

Registration Statement on Form F-3
General

1. Please revise the first bullet of the Explanatory Note to reflect the
inclusion of resale
 shares to be offered by selling shareholders in the base prospectus.
Cover Page

2. We note that your base prospectus covers the offering of up to $200
million of
 ordinary shares, warrants or units to be offered by you or selling
shareholders. Please
 revise your cover page to quantify the number of ordinary shares that
may be offered
 by the selling shareholders. Please also revise your disclosure, where
appropriate,
 to identify the selling shareholders and provide a brief description of
the initial
 May 21, 2025
Page 2

 transaction in which these securities were sold to the selling
shareholders. Refer to
 Item 501 of Regulation S-K and General Instruction II.H of Form F-3 for
guidance.
 We note that you do not appear to qualify for the omission of this
information under
 Rule 430B(b) because the company is not primarily eligible to use Form
F-3 under
 General Instruction I.B.1.
 We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence
of action by the staff.

 Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

 Please contact Tyler Howes at 202-551-3370 or Laura Crotty at
202-551-7614 with
any questions.

 Sincerely,

 Division of
Corporation Finance
 Office of Life
Sciences
cc: Xuelin Wang, Esq.
</TEXT>
</DOCUMENT>