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TriSalus
Life Sciences, Inc.

6272 W. 91st Ave.

Westminster, Colorado 80031

November 6, 2024

Securities and Exchange Commission

Division of Corporation Finance

Office of Industrial Applications
and Services

100 F. Street N.E.

Washington, D.C. 20549-3010

Attention: Robert Augustin

    Re:
    TriSalus Life Sciences, Inc.

    Registration Statement on Form S-3

    File No. 333-282882

Ladies and Gentlemen:

TriSalus Life Sciences, Inc. (the “Registrant”)
hereby requests that the U.S. Securities and Exchange Commission (the “Commission”) take appropriate action to cause
the above-referenced Registration Statement on Form S-3 to become effective on Friday, November 8, 2024, at 4:00 p.m., Eastern
Time, or as soon thereafter as is practicable or at such later time as the Registrant may orally request via telephone call to the staff
of the Commission. The Registrant hereby authorizes Dylan Kornbluth of Cooley LLP, counsel to the Registrant, to make such request on
its behalf.

Once the Registration Statement has been declared
effective, please orally confirm that event with Dylan Kornbluth of Cooley LLP, counsel to the Registrant, at (858) 550-6173.

[Signature Page Follows]

    Very truly yours,

    TRISALUS LIFE SCIENCES, INC.

    By:
    /s/ Mary
    Szela

    Name: Mary Szela

    Title: Chief Executive Officer

 cc:
                                                                                Carlos Ramirez, Cooley
                                            LLP

   Matthew T. Browne, Cooley LLP

   Dylan Kornbluth, Cooley LLP

[Company
Signature Page to Acceleration Request]