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Correspondence 0001104659-22-119414 from Xilio Therapeutics, Inc. (XLO)

Xilio Therapeutics, Inc.
Date: Nov. 16, 2022 · CIK: 0001840233 · Accession: 0001104659-22-119414

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File numbers found in text: 333-268264

Date
November 16, 2022
Author
René Russo
Form
CORRESP
Company
Xilio Therapeutics, Inc.

Letter

Xilio Therapeutics, Inc.

828 Winter Street, Suite 300

Waltham, MA 02451

November 16, 2022

VIA EDGAR SUBMISSION

U.S. Securities and Exchange Commission

Division of Corporation Finance, Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Christine Westbrook

Re: Xilio Therapeutics, Inc. Registration Statement on Form S-3 File No. 333-268264 Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Xilio Therapeutics, Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-268264), so that it may become effective at 4:00 p.m., Eastern time, on November 18, 2022, or as soon as practicable thereafter, or at such later time as the Registrant or its counsel may orally request via telephone call to the staff.

Very truly yours,
Xilio Therapeutics, Inc.

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CORRESP
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Xilio Therapeutics, Inc.

828 Winter Street, Suite 300

Waltham, MA 02451

November 16, 2022

VIA EDGAR SUBMISSION

U.S. Securities and Exchange Commission

Division of Corporation Finance, Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attention: Christine Westbrook

 Re: Xilio Therapeutics, Inc.
Registration Statement on Form S-3
File No. 333-268264
Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as
amended, Xilio Therapeutics, Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No.
333-268264), so that it may become effective at 4:00 p.m., Eastern time, on November 18, 2022, or as soon as practicable thereafter,
or at such later time as the Registrant or its counsel may orally request via telephone call to the staff.

    Very truly yours,

    Xilio Therapeutics, Inc.

    By:
    /s/ René Russo

    Name: René Russo

    Title: Chief Executive Officer