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Correspondence 0001193125-26-242232 from Xilio Therapeutics, Inc. (XLO)

Xilio Therapeutics, Inc.
Date: May 27, 2026 · CIK: 0001840233 · Accession: 0001193125-26-242232

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File numbers found in text: 333-295785

Date
May 27, 2026
Author
René Russo
Form
CORRESP
Company
Xilio Therapeutics, Inc.

Letter

Re:Xilio Therapeutics, Inc. Registration Statement on Form S-3 Filed May 12, 2026

May 27, 2026

VIA EDGAR SUBMISSION

U.S. Securities and Exchange Commission

Division of Corporation Finance, Office of Life Sciences

100 F Street, NE

Washington, DC 20549

Attention: Lauren Hamill

File No. 333-295785 Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Xilio Therapeutics, Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-295785), so that it may become effective at 4:00 p.m., Eastern Time, on May 29, 2026, or as soon as practicable thereafter.

Very truly yours,
XILIO THERAPEUTICS, Inc.

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CORRESP
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  CORRESP

  May 27, 2026

VIA EDGAR SUBMISSION

U.S. Securities and Exchange Commission

Division of Corporation Finance, Office of Life Sciences

100 F Street, NE

Washington, DC 20549

Attention:  Lauren Hamill

Re:Xilio Therapeutics, Inc.
Registration Statement on Form S-3
Filed May 12, 2026

File No. 333-295785
Request for Acceleration

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, Xilio Therapeutics, Inc. hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-295785), so that it may become effective at 4:00 p.m., Eastern Time, on May 29, 2026, or as soon as practicable thereafter.

Very truly yours,

XILIO THERAPEUTICS, Inc.

By:	/s/ René Russo

	Name: René Russo

	Title: President and Chief Executive Officer