Correspondence 0001493152-25-028149 from Biofrontera Inc. (BFRI)
Biofrontera Inc.
Date: Dec. 17, 2025 · CIK: 0001858685 · Accession: 0001493152-25-028149
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File numbers found in text: 333-291987
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CORRESP 1 filename1.htm Biofrontera Inc. · 660 Main Street, First Floor · Woburn, MA 01801 · USA VIA EDGAR December 17, 2025 Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Re: Biofrontera Inc. Registration Statement on Form S-1 (File No. 333-291987) Request for Acceleration of Effective Date Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended, Biofrontera Inc. (the " Registrant ") hereby requests that the Securities and Exchange Commission (the " Commission ") accelerate the effective date of the above-referenced Registration Statement on Form S-1 (as amended, the " Registration Statement ") so that the Registration Statement will be declared effective as of 4:30 p.m. Eastern time, on December 19, 2025, or as soon thereafter as practicable. The Registrant hereby also authorizes Stephen Older and Andrew Terjesen of McGuireWoods LLP to orally modify or withdraw this request for acceleration. Once the Registration Statement has been declared effective, please orally confirm that event with Stephen Older of McGuireWoods LLP at (212) 548-2122, or in his absence, Andrew Terjesen at (919) 835-5977. Thank you for your assistance in this matter. Very truly yours, Biofrontera Inc. /s/ E. Fred Leffler, III Name: E. Fred Leffler, III Title: Chief Financial Officer cc: Hermann Luebbert Biofrontera Inc. Stephen Older McGuireWoods LLP Biofrontera Inc. . 660 Main Street, First Floor . Woburn, MA 01801 . USA Contact Phone +1 781 245 1325 . E-Mail info-us@biofrontera.com . www.biofrontera-us.com