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UPLOAD Filing

Profusa, Inc.
Date: Sept. 9, 2025 · CIK: 0001859807 · Accession: 0000000000-25-009773

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File numbers found in text: 333-289958

Date
September 9, 2025
Author
Division of
Form
UPLOAD
Company
Profusa, Inc.

Letter

Re: Profusa, Inc. Registration Statement on Form S-1 Filed August 29, 2025 File No. 333-289958 Dear Ben Hwang:

September 9, 2025

Ben Hwang Chief Executive Officer Profusa, Inc. 626 Bancroft Way, Suite A Berkeley, CA 94710

We have conducted a limited review of your registration statement and have the following comment.

Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe a comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response.

After reviewing any amendment to your registration statement and the information you provide in response to this letter, we may have additional comments.

Registration Statement on Form S-1 General

1. We note your disclosure throughout the registration statement regarding your purchase of bitcoin, including your risk factor disclosures starting on page 54, your disclosures on page 80 that you intend to use the proceeds from your committed equity facility with Ascent entered into on July 28, 2025 for up to $100,000,000 of shares of your common stock "exclusively for the purchase of Bitcoin," and your statement on F-54 that "[as] of these June 30, 2025 financial statements, [you have] purchased $1.0 million of Bitcoin as part of [your] ongoing treasury strategy". Please disclose your current bitcoin and/or cryptocurrency holdings as of the date of the registration statement. September 9, 2025 Page 2

We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff.

Refer to Rules 460 and 461 regarding requests for acceleration. Please allow adequate time for us to review any amendment prior to the requested effective date of the registration statement.

Please contact Juan Grana at 202-551-6034 or Jane Park at 202-551-7439 with any other questions.

Sincerely,
Division of
Corporation Finance
Office of Industrial
Applications and
Services
cc: Marc Rivera, Esq.

Show Raw Text
<DOCUMENT>
<TYPE>TEXT-EXTRACT
<SEQUENCE>2
<FILENAME>filename2.txt
<TEXT>
 September 9, 2025

Ben Hwang
Chief Executive Officer
Profusa, Inc.
626 Bancroft Way, Suite A
Berkeley, CA 94710

 Re: Profusa, Inc.
 Registration Statement on Form S-1
 Filed August 29, 2025
 File No. 333-289958
Dear Ben Hwang:

 We have conducted a limited review of your registration statement and
have the
following comment.

 Please respond to this letter by amending your registration statement
and providing
the requested information. If you do not believe a comment applies to your
facts and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

 After reviewing any amendment to your registration statement and the
information
you provide in response to this letter, we may have additional comments.

Registration Statement on Form S-1
General

1. We note your disclosure throughout the registration statement regarding
your
 purchase of bitcoin, including your risk factor disclosures starting on
page 54, your
 disclosures on page 80 that you intend to use the proceeds from your
committed
 equity facility with Ascent entered into on July 28, 2025 for up to
$100,000,000 of
 shares of your common stock "exclusively for the purchase of Bitcoin,"
and your
 statement on F-54 that "[as] of these June 30, 2025 financial
statements, [you
 have] purchased $1.0 million of Bitcoin as part of [your] ongoing
treasury strategy".
 Please disclose your current bitcoin and/or cryptocurrency holdings as
of the date of
 the registration statement.
 September 9, 2025
Page 2

 We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence
of action by the staff.

 Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

 Please contact Juan Grana at 202-551-6034 or Jane Park at 202-551-7439
with any
other questions.

 Sincerely,

 Division of
Corporation Finance
 Office of Industrial
Applications and
 Services
cc: Marc Rivera, Esq.
</TEXT>
</DOCUMENT>