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CORRESP Filing

Lexeo Therapeutics, Inc.
Date: Nov. 25, 2025 · CIK: 0001907108 · Accession: 0001193125-25-297231

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File numbers found in text: 333-291269

Date
November 25, 2025
Author
Jenny R. Robertson
Form
CORRESP
Company
Lexeo Therapeutics, Inc.

Letter

Re: Lexeo Therapeutics, Inc. Registration Statement on Form S-3 File No. 333-291269 Acceleration Request Requested Date: November 26, 2025 Requested Time: 4:00 P.M. Eastern Time Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended, Lexeo Therapeutics, Inc. (the “ Company ”) hereby requests that the above-referenced Registration Statement on Form S-3 (File No. 333-291269) (the “ Registration Statement ”) be declared effective at the “Requested Date” and “Requested Time” set forth above or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission. Once the Registration Statement has been declared effective, please orally confirm that event with our counsel, Wilson Sonsini Goodrich & Rosati, P.C., by calling Megan J. Baier at (212) 497-7736.

Lexeo Therapeutics, Inc. 345 Park Avenue South, Floor 6 New York, New York 10010 November 25, 2025 VIA EDGAR U.S. Securities and Exchange Commission Office of Life Sciences Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-3720

Sincerely,
LEXEO THERAPEUTICS, INC.

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CORRESP
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 CORRESP

 Lexeo Therapeutics, Inc.
 345 Park Avenue South, Floor 6 New
York, New York 10010 November 25, 2025 VIA EDGAR
 U.S. Securities and Exchange Commission Office of Life
Sciences Division of Corporation Finance 100 F Street, N.E.
 Washington, D.C. 20549-3720

 Re:
 Lexeo Therapeutics, Inc.
 Registration Statement on Form S-3
 File No. 333-291269
 Acceleration Request Requested Date:
November 26, 2025 Requested Time: 4:00 P.M. Eastern Time
 Ladies and Gentlemen: Pursuant to Rule 461 under the Securities
Act of 1933, as amended, Lexeo Therapeutics, Inc. (the “ Company ”) hereby requests that the above-referenced Registration Statement on Form S-3 (File
 No. 333-291269) (the “ Registration Statement ”) be declared effective at the “Requested Date” and “Requested Time” set forth above or at such later time as the
Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission. Once the Registration Statement has been declared effective, please orally confirm that event
with our counsel, Wilson Sonsini Goodrich & Rosati, P.C., by calling Megan J. Baier at (212) 497-7736.

 Sincerely,

 LEXEO THERAPEUTICS, INC.

 /s/ Jenny R. Robertson

 Jenny R. Robertson

 Chief Legal Officer

 cc:
 R. Nolan Townsend
 Lexeo Therapeutics, Inc.
 Megan J. Baier David G. Sharon
 Wilson Sonsini Goodrich & Rosati, P.C.