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SEC Comment Letter 0000000000-22-013231 to Cadrenal Therapeutics, Inc. (CVKD)

Cadrenal Therapeutics, Inc.
Date: Dec. 8, 2022 · CIK: 0001937993 · Accession: 0000000000-22-013231

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File numbers found in text: 333-267562

Date
December 8, 2022
Author
Quang Pham
Form
UPLOAD
Company
Cadrenal Therapeutics, Inc.

Letter

United States securities and exchange commission logo December 8, 2022 Quang Pham Chief Executive Officer Cadrenal Therapeutics, Inc. 822 A1A North, Suite 320 Ponte Vedra, FL 32082 Re:Cadrenal Therapeutics, Inc. Amendment No. 3 to Registration Statement on Form S-1 Filed December 6, 2022 File No. 333-267562 Dear Quang Pham: We have reviewed your amended registration statement and have the following comments. In some of our comments, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comments apply to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to these comments, we may have additional comments. Amendment No. 3 to Registration Statement on Form S-1 Cover Page 1.Disclose whether your offering is contingent upon final approval of your Nasdaq listing on your cover page. Please ensure the disclosure is consistent with your underwriting agreement. Risk Factors Our stock price may be extremely volatile, and your investment in our common stock could suffer a decline in value. , page 44 2.We note recent instances of extreme stock price run-ups followed by rapid price declines and stock price volatility seemingly unrelated to company performance following a number of recent initial public offerings, particularly among companies with relatively

FirstName LastNameQuang Pham Comapany NameCadrenal Therapeutics, Inc. December 8, 2022 Page 2 FirstName LastName Quang Pham Cadrenal Therapeutics, Inc. December 8, 2022 Page 2 smaller public floats. Please revise this risk factor or include a separate risk factor addressing the potential for rapid and substantial price volatility and any known factors particular to your offering that may add to this risk and discuss the risks to investors when investing in stock where the price is changing rapidly. In addition, please clearly state that there is a risk of rapid and substantial price volatility and that any such volatility, including any stock-run up, may be unrelated to your actual or expected operating performance and financial condition or prospects, which could make it difficult for prospective investors to assess the rapidly changing value of your stock. You may contact Ibolya Ignat at 202-551-3636 or Al Pavot at 202-551-3738 if you have questions regarding comments on the financial statements and related matters. Please contact Dillon Hagius at 202-551-7967 or Jason Drory at 202-551-8342 with any other questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Leslie Marlow

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United States securities and exchange commission logo
December 8, 2022
Quang Pham
Chief Executive Officer
Cadrenal Therapeutics, Inc.
822 A1A North, Suite 320
Ponte Vedra, FL 32082
Re:Cadrenal Therapeutics, Inc.
Amendment No. 3 to Registration Statement on Form S-1
Filed December 6, 2022
File No. 333-267562
Dear Quang Pham:
            We have reviewed your amended registration statement and have the following
comments.  In some of our comments, we may ask you to provide us with information so we
may better understand your disclosure.
            Please respond to this letter by amending your registration statement and providing the
requested information.  If you do not believe our comments apply to your facts and
circumstances or do not believe an amendment is appropriate, please tell us why in your
response.
            After reviewing any amendment to your registration statement and the information you
provide in response to these comments, we may have additional comments.
Amendment No. 3 to Registration Statement on Form S-1
Cover Page
1.Disclose whether your offering is contingent upon final approval of your Nasdaq listing
on your cover page.  Please ensure the disclosure is consistent with your underwriting
agreement.
Risk Factors
Our stock price may be extremely volatile, and your investment in our common stock could
suffer a decline in value. , page 44
2.We note recent instances of extreme stock price run-ups followed by rapid price declines
and stock price volatility seemingly unrelated to company performance following a
number of recent initial public offerings, particularly among companies with relatively

 FirstName LastNameQuang Pham
 Comapany NameCadrenal Therapeutics, Inc.
 December 8, 2022 Page 2
 FirstName LastName
Quang Pham
Cadrenal Therapeutics, Inc.
December 8, 2022
Page 2
smaller public floats. Please revise this risk factor or include a separate risk factor
addressing the potential for rapid and substantial price volatility and any known factors
particular to your offering that may add to this risk and discuss the risks to investors when
investing in stock where the price is changing rapidly. In addition, please clearly state that
there is a risk of rapid and substantial price volatility and that any such volatility,
including any stock-run up, may be unrelated to your actual or expected operating
performance and financial condition or prospects, which could make it difficult for
prospective investors to assess the rapidly changing value of your stock.
            You may contact Ibolya Ignat at 202-551-3636 or Al Pavot at 202-551-3738 if you have
questions regarding comments on the financial statements and related matters. Please contact
Dillon Hagius at 202-551-7967 or Jason Drory at 202-551-8342 with any other questions.
Sincerely,
Division of Corporation Finance
Office of Life Sciences
cc:       Leslie Marlow